Approach to mucosal bleeding in an adolescent with FXI deficiency

Ruchika Sharma; Bryce A. Kerlin

doi:10.1007/978-3-030-31661-7_7

Approach to mucosal bleeding in an adolescent with FXI deficiency

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Factor XI is a coagulation factor produced in the liver that is activated by thrombin and reinforces the intrinsic clotting pathway. Factor XI deficiency is mostly autosomal recessive and more commonly seen in Ashkenazi Jews. Patients usually present with bleeding at sites of high fibrinolytic activity. Subtypes and management options are discussed further in the context of a clinical case.

Original language	English (US)
Title of host publication	Pediatric Bleeding Disorders
Subtitle of host publication	A Clinical Casebook
Publisher	Springer International Publishing
Pages	65-70
Number of pages	6
ISBN (Electronic)	9783030316617
ISBN (Print)	9783030316600
DOIs	https://doi.org/10.1007/978-3-030-31661-7_7
State	Published - Jan 1 2020
Externally published	Yes

Keywords

Bleeding disorder
Factor XI concentrates
Factor XI deficiency
Intrinsic coagulation pathway

ASJC Scopus subject areas

Medicine(all)

Access to Document

10.1007/978-3-030-31661-7_7

Cite this

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abstract = "Factor XI is a coagulation factor produced in the liver that is activated by thrombin and reinforces the intrinsic clotting pathway. Factor XI deficiency is mostly autosomal recessive and more commonly seen in Ashkenazi Jews. Patients usually present with bleeding at sites of high fibrinolytic activity. Subtypes and management options are discussed further in the context of a clinical case.",

keywords = "Bleeding disorder, Factor XI concentrates, Factor XI deficiency, Intrinsic coagulation pathway",

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AB - Factor XI is a coagulation factor produced in the liver that is activated by thrombin and reinforces the intrinsic clotting pathway. Factor XI deficiency is mostly autosomal recessive and more commonly seen in Ashkenazi Jews. Patients usually present with bleeding at sites of high fibrinolytic activity. Subtypes and management options are discussed further in the context of a clinical case.

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KW - Factor XI concentrates

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KW - Intrinsic coagulation pathway

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Approach to mucosal bleeding in an adolescent with FXI deficiency

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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