Approach to mucosal bleeding in an adolescent with FXI deficiency

Ruchika Sharma, Bryce A. Kerlin

Research output: Chapter in Book/Report/Conference proceedingChapter


Factor XI is a coagulation factor produced in the liver that is activated by thrombin and reinforces the intrinsic clotting pathway. Factor XI deficiency is mostly autosomal recessive and more commonly seen in Ashkenazi Jews. Patients usually present with bleeding at sites of high fibrinolytic activity. Subtypes and management options are discussed further in the context of a clinical case.

Original languageEnglish (US)
Title of host publicationPediatric Bleeding Disorders
Subtitle of host publicationA Clinical Casebook
PublisherSpringer International Publishing
Number of pages6
ISBN (Electronic)9783030316617
ISBN (Print)9783030316600
StatePublished - Jan 1 2020
Externally publishedYes


  • Bleeding disorder
  • Factor XI concentrates
  • Factor XI deficiency
  • Intrinsic coagulation pathway

ASJC Scopus subject areas

  • Medicine(all)


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