Application of mid-frequency ventilation in an animal model of lung injury: A pilot study

Eduardo Mireles-Cabodevila, Robert L. Chatburn, Tracy L. Thurman, Luis M. Zabala, Shirley J. Holt, Christopher J. Swearingen, Mark J. Heulitt

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


BACKGROUND: Mid-frequency ventilation (MFV) is a mode of pressure control ventilation based on an optimal targeting scheme that maximizes alveolar ventilation and minimizes tidal volume (VT). This study was designed to compare the effects of conventional mechanical ventilation using a lung-protective strategy with MFV in a porcine model of lung injury. Our hypothesis was that MFV can maximize ventilation at higher frequencies without adverse consequences. We compared ventilation and hemodynamic outcomes between conventional ventilation and MFV. METHODS: This was a prospective study of 6 live Yorkshire pigs (10 ± 0.5 kg). The animals were subjected to lung injury induced by saline lavage and injurious conventional mechanical ventilation. Baseline conventional pressure control continuous mandatory ventilation was applied with VT= 6 mL/kg and PEEP determined using a decremental PEEP trial. A manual decision support algorithm was used to implement MFV using the same conventional ventilator. We measured PaCO2, PaO2, end-tidal carbon dioxide, cardiac output, arterial and venous blood oxygen saturation, pulmonary and systemic vascular pressures, and lactic acid. RESULTS: The MFV algorithm produced the same minute ventilation as conventional ventilation but with lower VT (-1 ± 0.7 mL/kg) and higher frequency (32.1 ± 6.8 vs 55.7 ±15.8 breaths/min, P <.002). There were no differences between conventional ventilation and MFV for mean airway pressures (16.1 ± 1.3 vs 16.4 ± 2 cmH2O, P =75) even when auto-PEEP was higher (0.6 ± 0.9 vs 2.4 ± 1.1 cm H2O, P =.02). There were no significant differences in any hemodynamic measurements, although heart rate was higher during MFV. CONCLUSIONS: In this pilot study, we demonstrate that MFV allows the use of higher breathing frequencies and lower VT than conventional ventilation to maximize alveolar ventilation. We describe the ventilatory or hemodynamic effects of MFV. We also demonstrate that the application of a decision support algorithm to manage MFV is feasible.

Original languageEnglish (US)
Pages (from-to)1619-1627
Number of pages9
JournalRespiratory care
Issue number11
StatePublished - Nov 2014


  • Algorithms
  • Auto-PEEP
  • Decision support
  • Hemodynamic
  • Lung injury
  • Mechanical ventilation
  • Optimum ventilation
  • Pulmonary gas exchange
  • Targeting scheme
  • Ventilation protocol

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine


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