Application of artificial intelligence to chronic kidney disease mineral bone disorder

Eleanor D. Lederer, Mahmoud M. Sobh, Michael E. Brier, Adam E. Gaweda

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The global derangement of mineral metabolism that accompanies chronic kidney disease (CKD-MBD) is a major driver of the accelerated mortality for individuals with kidney disease. Advances in the delivery of dialysis, in the composition of phosphate binders, and in the therapies directed towards secondary hyperparathyroidism have failed to improve the cardiovascular event profile in this population. Many obstacles have prevented progress in this field including the incomplete understanding of pathophysiology, the lack of clinical targets for early stages of chronic kidney disease, and the remarkably wide diversity in clinical manifestations. We describe in this review a novel approach to CKD-MBD combining mathematical modelling of biologic processes with machine learning artificial intelligence techniques as a tool for the generation of new hypotheses and for the development of innovative therapeutic approaches to this syndrome. Clinicians need alternative targets of therapy, tools for risk profile assessment, and new therapies to address complications early in the course of disease and to personalize therapy to each individual. The complexity of CKD-MBD suggests that incorporating artificial intelligence techniques into the diagnostic, therapeutic, and research armamentarium could accelerate the achievement of these goals.

Original languageEnglish (US)
Article numbersfae143
JournalClinical Kidney Journal
Volume17
Issue number6
DOIs
StatePublished - Jun 1 2024

Keywords

  • artificial intelligence
  • chronic kidney disease
  • mineral metabolism

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

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