Appetite control: why we fail to stop eating even when we are full?

Kristen Davis, Young Jai You

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


We often eat more than our body needs. We live in an environment where high calorie food is abundant and physical activities are limited. Living in this environment, maintaining healthy bodyweight becomes challenging and obesity becomes a social burden. Why do we continue to eat even after the metabolic needs are satisfied? Feeding is an ancient behavior essential to survive. Thus the mechanisms to regulate appetite, energy expenditure, and energy storage are well conserved throughout animals. Based on this conservation, we study why we fail to control appetite using a simple genetic model system C. elegans. We have discovered certain genetic components that when misregulated have animals eat more and store more fat. In this review we discuss how these genes work in the appetite control circuit to ultimately understand overall appetite control behavior. We will also briefly discuss how social influence affects feeding regardless of the metabolic status of an animal.

Original languageEnglish (US)
Pages (from-to)169-174
Number of pages6
JournalFrontiers in Biology
Issue number3
StatePublished - Jun 1 2014
Externally publishedYes


  • C. elegans
  • TGFβ
  • appetite
  • cGMP
  • obesity
  • satiety

ASJC Scopus subject areas

  • Biotechnology
  • Ecology, Evolution, Behavior and Systematics
  • Ecology
  • Genetics


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