Apoptotic cells initiate endothelial cell sprouting via electrostatic signaling

Zhang Weihua, Rachel Tsan, Alan J. Schroit, Isaiah J. Fidler

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


Angiogenesis, the development of new blood vessels from preexisting vessels, is crucial to tissue growth, repair, and maintenance. This process begins with the formation of endothelial cell sprouts followed by the proliferation and migration of neighboring endothelial cells along the preformed extensions. The initiating event and mechanism of sprouting is not known. We show that the phenotypic expression of negatively charged membrane surface in apoptotic cells initiates the formation of directional endothelial cell sprouts that extend toward the dying cells by a mechanism that involves endothelial cell membrane hyperpolarization and cytoskeleton reorganization but is independent of diffusible molecules.

Original languageEnglish (US)
Pages (from-to)11529-11535
Number of pages7
JournalCancer research
Issue number24
StatePublished - Dec 15 2005

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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