Abstract
The receptor for advanced glycation end products (RAGE) is a member of the immunoglobulin gene superfamily, encoded within the major histocompatability complex class III region. Its multiple ligands include the high mobility group box 1 chromatin binding protein, HMGB1. Recently we reported that RAGE-HMGB1 critically regulates autophagy and apoptosis in pancreatic cancer cells in vivo and in vitro in response to chemotherapy. RAGE inhibits apoptosis ("programmed cell death") by a p53 transcription-independent pathway during the response to chemotherapeutic agents. RAGE sustains autophagy ("programmed cell survival") associated with decreased phosphorylation of the mammalian target of rapamycin (mTOR) and increased Beclin 1-Vps34 interaction. These findings provide insight into how autophagy- and apoptosis-crossregulatory molecules interact in response to cellular stress including tumor therapy.
Original language | English (US) |
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Pages (from-to) | 91-93 |
Number of pages | 3 |
Journal | Autophagy |
Volume | 7 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2011 |
Externally published | Yes |
Keywords
- Apoptosis
- Autophagy
- Beclin 1
- DAMP
- Pancreatic cancer
- RAGE
- mTOR
- p53
- vps34
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology