Apoptosis induced by Dioscin in Hela cells

Jing Cai, Mingjie Liu, Zhao Wang, Yong Ju

Research output: Contribution to journalArticlepeer-review

110 Scopus citations


Dioscin, a saponin extracted from the root of Polygonatum Zanlanscianense Pamp, markedly inhibited proliferation of Hela cells. The results indicated that Hela cells underwent apoptosis in dose- and time-dependent manners when treated with Dioscin. Caspase-3, -8 and -9 activities were also detected. The low enzymatic activity of caspase-8 and high activity of caspase-9 showed that the mitochondrial pathway was activated in apoptosis. The reduced expression of the survival protein Bcl-2 also confirmed this result. These studies may be significant in finding a new drug to treat human cervical cancer.

Original languageEnglish (US)
Pages (from-to)193-196
Number of pages4
JournalBiological and Pharmaceutical Bulletin
Issue number2
StatePublished - Feb 2002
Externally publishedYes


  • Apoptosis
  • Bcl-2
  • Caspase
  • Dioscin
  • Hela

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science


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