S. Malladi, M. Challa-Malladi, S. B. Bratton

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations


Apoptosis plays a critical role during normal development and homeostasis of adult tissues. Consequently, deregulation of apoptosis is commonly associated with diseases ranging from cancer to neurodegeneration. Toxicants also induce cell death via apoptosis, and in most cases this involves the activation of cysteinyl aspartate-specific proteases (caspases). In this chapter, we describe in biochemical and structural detail the mechanisms that mediate the activation of caspases within large multimeric complexes, including the death-inducing signaling complex (DISC) and the Apaf-1 apoptosome. In addition, we cover each of the factors known to directly or indirectly regulate the activation (or activity) of caspases, including inhibitor of apoptosis (IAP) and BCL-2 family members, as well as their antagonists.

Original languageEnglish (US)
Title of host publicationComprehensive Toxicology
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Number of pages36
ISBN (Print)9780080468846
StatePublished - Jan 1 2010
Externally publishedYes


  • Apaf-1
  • Apoptosome
  • BCL-2
  • Caspases
  • DISC
  • Inhibitor of apoptosis (IAP) proteins

ASJC Scopus subject areas

  • General Medicine


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