Abstract
ApoE, a common ligand for all members of the evolutionary ancient LDL receptor gene family, is the major genetic modifier of the age of onset of Alzheimer's disease. The underlying molecular mechanisms remain shrouded in mystery, but the numerous critical functions of ApoE receptors within and outside the nervous system that have recently emerged make it likely that these multifunctional signal modulators participate in Alzheimer's disease pathogenesis. This review attempts to summarize the most recent and relevant findings in this area.
Original language | English (US) |
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Pages (from-to) | 190-196 |
Number of pages | 7 |
Journal | Current opinion in lipidology |
Volume | 20 |
Issue number | 3 |
DOIs | |
State | Published - Jun 2009 |
Keywords
- Dementia
- LDL receptor family
- Neuronal survival
- Synaptic plasticity
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Molecular Biology
- Genetics
- Nutrition and Dietetics
- Cardiology and Cardiovascular Medicine
- Cell Biology