Apical-basal polarity, Wnt signaling and vertebrate organogenesis

Research output: Contribution to journalReview articlepeer-review

52 Scopus citations


Wnt proteins elicit several distinct signal transduction cascades and regulate multiple cellular processes that have proven essential for embryonic development in all metazoans investigated. During embryonic development, epithelial cells become polarized along two axes: apical/basal and within the plane of the tissue. Growing evidence suggests that polarization along each axis is essential for normal embryonic development and that this polarization is regulated in part by the different branches of the Wnt pathway. Here, we review the role of A/B cell polarity in vertebrate organogenesis with a focus on the involvement of canonical Wnt signaling in this process.

Original languageEnglish (US)
Pages (from-to)214-222
Number of pages9
JournalSeminars in Cell and Developmental Biology
Issue number2
StatePublished - Apr 2006


  • Non-canonical
  • Organogenesis
  • Planar cell polarity, Tissue polarity
  • Wnt

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology


Dive into the research topics of 'Apical-basal polarity, Wnt signaling and vertebrate organogenesis'. Together they form a unique fingerprint.

Cite this