Apical-basal polarity, Wnt signaling and vertebrate organogenesis

Courtney Karner; Keith A. Wharton; Thomas J. Carroll

doi:10.1016/j.semcdb.2006.05.007

Apical-basal polarity, Wnt signaling and vertebrate organogenesis

Courtney Karner, Keith A. Wharton, Thomas J. Carroll

Research output: Contribution to journal › Review article › peer-review

53 Scopus citations

Abstract

Wnt proteins elicit several distinct signal transduction cascades and regulate multiple cellular processes that have proven essential for embryonic development in all metazoans investigated. During embryonic development, epithelial cells become polarized along two axes: apical/basal and within the plane of the tissue. Growing evidence suggests that polarization along each axis is essential for normal embryonic development and that this polarization is regulated in part by the different branches of the Wnt pathway. Here, we review the role of A/B cell polarity in vertebrate organogenesis with a focus on the involvement of canonical Wnt signaling in this process.

Original language	English (US)
Pages (from-to)	214-222
Number of pages	9
Journal	Seminars in Cell and Developmental Biology
Volume	17
Issue number	2
DOIs	https://doi.org/10.1016/j.semcdb.2006.05.007
State	Published - Apr 2006

Keywords

Non-canonical
Organogenesis
Planar cell polarity, Tissue polarity
Wnt

ASJC Scopus subject areas

Developmental Biology
Cell Biology

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10.1016/j.semcdb.2006.05.007

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AU - Wharton, Keith A.

AU - Carroll, Thomas J.

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AB - Wnt proteins elicit several distinct signal transduction cascades and regulate multiple cellular processes that have proven essential for embryonic development in all metazoans investigated. During embryonic development, epithelial cells become polarized along two axes: apical/basal and within the plane of the tissue. Growing evidence suggests that polarization along each axis is essential for normal embryonic development and that this polarization is regulated in part by the different branches of the Wnt pathway. Here, we review the role of A/B cell polarity in vertebrate organogenesis with a focus on the involvement of canonical Wnt signaling in this process.

KW - Non-canonical

KW - Organogenesis

KW - Planar cell polarity, Tissue polarity

KW - Wnt

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Apical-basal polarity, Wnt signaling and vertebrate organogenesis

Abstract

Keywords

ASJC Scopus subject areas

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