Abstract
We sought to determine whether patients requiring more aphereses to obtain adequate numbers of CD34 cells had delayed hematopoietic recovery following autologous transplantation. We identified 496 consecutive individuals with lymphoma who underwent hematopoietic stem cell mobilization using etoposide and G-CSF and first autologous transplantation. In multivariate analysis, increased apheresis days as a continuous and as a categorical variable at 5/5 days significantly predicted neutrophil recovery. Apheresis days fell just short of significance (P0.06) as a predictor of platelet recovery in multivariate analysis. Increased apheresis days (as both continuous and categorical variables) were also predictive of treatment-related myelodysplastic syndrome/AML. Patients who underwent 5 days of pheresis had significantly worse survival (P0.001) than patients with less pheresis days owing to significantly higher relapse mortality (P0.001).
Original language | English (US) |
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Pages (from-to) | 1519-1525 |
Number of pages | 7 |
Journal | Bone Marrow Transplantation |
Volume | 46 |
Issue number | 12 |
DOIs | |
State | Published - Dec 2011 |
Externally published | Yes |
Keywords
- CD34+ cells
- apheresis days
- autologous transplantation
- hematopoietic recovery
ASJC Scopus subject areas
- Hematology
- Transplantation