Antiplatelet Effect of Ketorolac in Children After Congenital Cardiac Surgery

John S. Kim, Jon Kaufman, Sonali S. Patel, Marilyn Manco-Johnson, Jorge Di Paola, Eduardo M. da Cruz

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Background: Ketorolac is used for pediatric analgesia after surgery despite its known platelet inhibition via the arachidonic acid (AA) pathway. The degree of platelet inhibitory effect after cardiac surgery is not well characterized. Thromboelastography with platelet mapping (TEG-PM) is emerging as a frequently used test to evaluate platelet inhibition via the AA pathway. Methods: Post hoc analysis of a data set collected in a prospective observational cohort study evaluating platelet inhibition in children after congenital heart surgery with cardiopulmonary bypass (CPB). Categorization into two groups: (1) received ketorolac and (2) did not receive ketorolac for analgesia after surgery. The TEG-PM was evaluated at two time points (prior to surgery and 12-48 hours after CPB). Results: Fifty-three children were studied; mean age was 6.6 (range: 0.07-16.7) years and 45% (n = 24) were female. Participants were distributed into two groups by ketorolac use, 41 within the ketorolac group and 12 in the no ketorolac group. All 41 participants who received ketorolac had platelet inhibition and 11 (91.7%) of 12 participants who did not receive ketorolac had normal platelet function after surgery (P <.0001). There was no difference in patient characteristics or clinical data between the two groups. Conclusions: Ketorolac use in a cohort of children after congenital cardiac surgery was associated with platelet inhibition via the AA pathway when evaluated by TEG-PM.

Original languageEnglish (US)
Pages (from-to)651-658
Number of pages8
JournalWorld Journal for Pediatric and Congenital Heart Surgery
Issue number6
StatePublished - Nov 1 2018
Externally publishedYes


  • blood
  • coagulation/anticoagulation; cardiopulmonary bypass (CPB)
  • congenital heart disease (CHD)
  • congenital heart surgery
  • hematology
  • pediatric

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health
  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Antiplatelet Effect of Ketorolac in Children After Congenital Cardiac Surgery'. Together they form a unique fingerprint.

Cite this