TY - JOUR
T1 - Antibiotic concentrations in pus and bone of children with osteomyelitis
AU - Tetzlaff, Thomas R.
AU - Howard, Jorge B.
AU - McCracken, George H.
AU - Calderon, Ernesto
AU - Larrondo, Jose
N1 - Funding Information:
From the Department of Pediatrics, University of Texas Southwestern Medical School, and Departments of Pediatrics and Orthopedic Surgery, Hospital infantil, IMA N. Supported by grants from Lilly Research Laboratories and The John A. Hartford Foundation. *Reprint address: Department of Pediatrics, Univ Tx Southwestern Medical School, 5323 Harry Hines Blvd., Dallas, TX 75235.
PY - 1978/1
Y1 - 1978/1
N2 - Pharmacologic data are presented on 39 children treated for osteomyelitis with one of the following antibiotics: methicillin, dicloxacillin, cephaloridine, or cefazolin. The concentrations of drug in pus and bone were correlated with serum concentrations, with the susceptibilities of Staphylococcus aureus strains isolated from the patients, and with the degree of drug protein-binding. The penetration of the antibiotics into pus and bone was similar for the two penicillins and for the two cephalosporins despite the disparate protein-binding affinities of these drugs. The agents attained concentrations in tissues that were at least several fold, and often more than tenfold, greater than the MIC and MBC values for the S. aureus stains. These data provide a basis for selection of antimicrobial agents for treatment of osteomyelitis.
AB - Pharmacologic data are presented on 39 children treated for osteomyelitis with one of the following antibiotics: methicillin, dicloxacillin, cephaloridine, or cefazolin. The concentrations of drug in pus and bone were correlated with serum concentrations, with the susceptibilities of Staphylococcus aureus strains isolated from the patients, and with the degree of drug protein-binding. The penetration of the antibiotics into pus and bone was similar for the two penicillins and for the two cephalosporins despite the disparate protein-binding affinities of these drugs. The agents attained concentrations in tissues that were at least several fold, and often more than tenfold, greater than the MIC and MBC values for the S. aureus stains. These data provide a basis for selection of antimicrobial agents for treatment of osteomyelitis.
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U2 - 10.1016/S0022-3476(78)80095-X
DO - 10.1016/S0022-3476(78)80095-X
M3 - Article
C2 - 619056
AN - SCOPUS:0017802631
SN - 0022-3476
VL - 92
SP - 135
EP - 140
JO - Journal of Pediatrics
JF - Journal of Pediatrics
IS - 1
ER -