Anti-aging effects of nutritional modification: The state of the science on calorie restriction

L. Anne Gilmore, Eric Ravussin, Leanne M. Redman

Research output: Chapter in Book/Report/Conference proceedingChapter


Caloric restriction (CR) has been shown to retard the aging process and ward off diseases, extending the median and maximal lifespan in various models and species. Caloric restriction in humans has been studied through 1) observational studies including the Centenarians from Okinawa, the Biosphere 2 experiment, and the Cronies and 2) randomized clinical trials including the Vallejo Study and CALERIE Phase I. There is increasing evidence that CR improves metabolic and endocrine health, biomarkers of longevity, and decrease cardiovascular and diabetes risk factors even in non-obese humans without negative effects on mood, hunger, quality of life, or cognitive function. Despite the positive effects seen with CR on overall human health, more longitudinal research is needed to determine the ability of CR to increase longevity and lifespan in humans.

Original languageEnglish (US)
Title of host publicationHandbook of Clinical Nutrition and Aging, Third Edition
PublisherSpringer New York
Number of pages20
ISBN (Electronic)9781493919291
ISBN (Print)9781493919284
StatePublished - Jan 1 2015
Externally publishedYes


  • Aging
  • Caloric restriction
  • Calorie restriction
  • Hormones
  • Humans
  • Longevity
  • Metabolism
  • Physical activity
  • Quality of life
  • Weight loss

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)


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