Anti-aging effects of nutritional modification: The state of the science on calorie restriction

L. Anne Gilmore; Eric Ravussin; Leanne M. Redman

doi:10.1007/978-1-4939-1929-1_20

Anti-aging effects of nutritional modification: The state of the science on calorie restriction

L. Anne Gilmore, Eric Ravussin, Leanne M. Redman

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Caloric restriction (CR) has been shown to retard the aging process and ward off diseases, extending the median and maximal lifespan in various models and species. Caloric restriction in humans has been studied through 1) observational studies including the Centenarians from Okinawa, the Biosphere 2 experiment, and the Cronies and 2) randomized clinical trials including the Vallejo Study and CALERIE Phase I. There is increasing evidence that CR improves metabolic and endocrine health, biomarkers of longevity, and decrease cardiovascular and diabetes risk factors even in non-obese humans without negative effects on mood, hunger, quality of life, or cognitive function. Despite the positive effects seen with CR on overall human health, more longitudinal research is needed to determine the ability of CR to increase longevity and lifespan in humans.

Original language	English (US)
Title of host publication	Handbook of Clinical Nutrition and Aging, Third Edition
Publisher	Springer New York
Pages	315-334
Number of pages	20
ISBN (Electronic)	9781493919291
ISBN (Print)	9781493919284
DOIs	https://doi.org/10.1007/978-1-4939-1929-1_20
State	Published - Jan 1 2015
Externally published	Yes

Keywords

Aging
Caloric restriction
Calorie restriction
Hormones
Humans
Longevity
Metabolism
Physical activity
Quality of life
Weight loss

ASJC Scopus subject areas

Medicine(all)
Biochemistry, Genetics and Molecular Biology(all)

Access to Document

10.1007/978-1-4939-1929-1_20

Cite this

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abstract = "Caloric restriction (CR) has been shown to retard the aging process and ward off diseases, extending the median and maximal lifespan in various models and species. Caloric restriction in humans has been studied through 1) observational studies including the Centenarians from Okinawa, the Biosphere 2 experiment, and the Cronies and 2) randomized clinical trials including the Vallejo Study and CALERIE Phase I. There is increasing evidence that CR improves metabolic and endocrine health, biomarkers of longevity, and decrease cardiovascular and diabetes risk factors even in non-obese humans without negative effects on mood, hunger, quality of life, or cognitive function. Despite the positive effects seen with CR on overall human health, more longitudinal research is needed to determine the ability of CR to increase longevity and lifespan in humans.",

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Anti-aging effects of nutritional modification: The state of the science on calorie restriction

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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