Abstract
Objective: To determine whether antepartum phenobarbital and vitamin K reduce the risk of intraventricular hemorrhage in premature newborns. Methods: Patients at imminent risk for spontaneous or indicated premature delivery between 24–34 weeks’ gestation were randomized to receive either placebo or vitamin K and phenobarbital. All patients received betamethasone and antibiotics and were managed uniformly by a single perinatal group in one hospital. All newborns were managed uniformly in the same facility by a single neonatal group. Results: There was a nonsignificant reduction in all grades of intraventricular hemorrhage in the treatment group when compared to the placebo group (48.2 versus 38.3%; P > .05). Frequencies were reduced for severe intraventricular hemorrhage (grades 3 and 4) (6.0 versus 2.5%; P > .05) and mild intraventricular hemorrhage (grades 1 and 2) (42.2 versus 35.8%; P > .05). Conclusions: Antepartum phenobarbital and vitamin K effected a nonsignificant reduction in both mild and severe intraventricular hemorrhage. The incidence of severe intraventricular hemorrhage in our control group was significantly less than that observed in previous studies.
Original language | English (US) |
---|---|
Pages (from-to) | 70-76 |
Number of pages | 7 |
Journal | Obstetrics and gynecology |
Volume | 83 |
Issue number | 1 |
State | Published - Jan 1994 |
ASJC Scopus subject areas
- Obstetrics and Gynecology