TY - JOUR
T1 - Ankylosing spondylitis
T2 - New improved treatment, new improved models
AU - Taurog, Joel D.
PY - 2006
Y1 - 2006
N2 - Ankylosing spondylitis (AS) is an underdiagnosed chronic inflammatory disease. The etiology is largely genetic, with strong association with the allele HLA-B27. Pathogenesis is poorly understood, but dramatic benefit from anti-TNF therapy indicates that the cytokine TNF is centrally involved. Rodent models are available to study several aspects of AS pathogenesis: the role HLA-B27, the process of spinal and peripheral joint calcification, immune responses to candidate antigens and the role of TNF.
AB - Ankylosing spondylitis (AS) is an underdiagnosed chronic inflammatory disease. The etiology is largely genetic, with strong association with the allele HLA-B27. Pathogenesis is poorly understood, but dramatic benefit from anti-TNF therapy indicates that the cytokine TNF is centrally involved. Rodent models are available to study several aspects of AS pathogenesis: the role HLA-B27, the process of spinal and peripheral joint calcification, immune responses to candidate antigens and the role of TNF.
UR - http://www.scopus.com/inward/record.url?scp=33645863139&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33645863139&partnerID=8YFLogxK
U2 - 10.1016/j.ddmod.2006.03.007
DO - 10.1016/j.ddmod.2006.03.007
M3 - Review article
AN - SCOPUS:33645863139
SN - 1740-6757
VL - 3
SP - 27
EP - 31
JO - Drug Discovery Today: Disease Models
JF - Drug Discovery Today: Disease Models
IS - 1
ER -