Angiotensin receptors, autoimmunity, and preeclampsia

Yang Xia, Chenyi Zhou Cissy, Susan M. Ramin, Rodney E. Kellems

Research output: Contribution to journalShort surveypeer-review

52 Scopus citations

Abstract

Preeclampsia is a pregnancy-induced hypertensive disorder that causes substantial maternal and fetal morbidity and mortality. Despite being a leading cause of maternal death and a major contributor to maternal and perinatal morbidity, the mechanisms responsible for the pathogenesis of preeclampsia are poorly understood. Recent studies indicate that women with preeclampsia have autoantibodies that activate the angiotensin receptor, AT1, and that autoantibody-mediated receptor activation contributes to pathophysiology associated with preeclampsia. The research reviewed here raises the intriguing possibility that preeclampsia may be a pregnancy-induced autoimmune disease.

Original languageEnglish (US)
Pages (from-to)3391-3395
Number of pages5
JournalJournal of Immunology
Volume179
Issue number6
DOIs
StatePublished - Sep 15 2007
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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