TY - JOUR
T1 - Angiogenic role of LYVE-1-positive macrophages in adipose tissue
AU - Cho, Chung Hyun
AU - Koh, Young Jun
AU - Han, Jinah
AU - Sung, Hoon Ki
AU - Lee, Hyuek Jong
AU - Morisada, Tohru
AU - Schwendener, Reto A.
AU - Brekken, Rolf A.
AU - Kang, Guson
AU - Oike, Yuichi
AU - Choi, Tae Saeng
AU - Suda, Toshio
AU - Yoo, Ook Joon
AU - Koh, Gou Young
PY - 2007/3
Y1 - 2007/3
N2 - Here we report the discovery of a characteristic dense vascular network (DVN) in the tip portion of epididymal adipose tissue in adult mice. The DVN is formed by angiogenesis rather than by vasculogenesis, and has functional blood circulation. This DVN and its subsequent branching may provide a new functional route for adipogenesis. The recruitment, infiltration, and accumulation of bone marrow-derived LYVE-1 macrophages in the tip region are crucial for the formation of the DVN. Matrix metalloproteinases (MMPs) and the VEGF-VEGFR2 system are responsible not only for the formation of the DVN, but also for the recruitment and infiltration of LYVE-1 macrophages into the epididymal adipose tissue tip region. SDF-1, but not the MCP-1-CCR2 system, is a critical factor in recruitment and ongoing retention of macrophages in this area. We also demonstrate that the tip region of epididymal adipose tissue is highly hypoxic, and thus provides a microenvironment conducive to the high expression and enhanced activities of VEGF, VEGFR2, MMPs, and SDF-1 in autocrine and paracrine manners, to create an ideal niche for the recruitment, retention, and angiogenic action of macrophages. These findings shed light on the complex interplay between macrophage infiltration, angiogenesis, and adipogenesis in the tip region of adult epididymal adipose tissue, and provide novel insight into the regulation of alternative outgrowth of adipose tissue.
AB - Here we report the discovery of a characteristic dense vascular network (DVN) in the tip portion of epididymal adipose tissue in adult mice. The DVN is formed by angiogenesis rather than by vasculogenesis, and has functional blood circulation. This DVN and its subsequent branching may provide a new functional route for adipogenesis. The recruitment, infiltration, and accumulation of bone marrow-derived LYVE-1 macrophages in the tip region are crucial for the formation of the DVN. Matrix metalloproteinases (MMPs) and the VEGF-VEGFR2 system are responsible not only for the formation of the DVN, but also for the recruitment and infiltration of LYVE-1 macrophages into the epididymal adipose tissue tip region. SDF-1, but not the MCP-1-CCR2 system, is a critical factor in recruitment and ongoing retention of macrophages in this area. We also demonstrate that the tip region of epididymal adipose tissue is highly hypoxic, and thus provides a microenvironment conducive to the high expression and enhanced activities of VEGF, VEGFR2, MMPs, and SDF-1 in autocrine and paracrine manners, to create an ideal niche for the recruitment, retention, and angiogenic action of macrophages. These findings shed light on the complex interplay between macrophage infiltration, angiogenesis, and adipogenesis in the tip region of adult epididymal adipose tissue, and provide novel insight into the regulation of alternative outgrowth of adipose tissue.
KW - Adipogenesis
KW - Angiogenesis
KW - Lymphatic vessel hyaluronan receptor 1
KW - Macrophages
KW - Matrix metalloproteinases
KW - Monocyte chemoattractant protein-1
KW - Vascular endothelial growth factor receptors
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U2 - 10.1161/01.RES.0000259564.92792.93
DO - 10.1161/01.RES.0000259564.92792.93
M3 - Article
C2 - 17272806
AN - SCOPUS:33947520741
SN - 0009-7330
VL - 100
SP - e47-e57
JO - Circulation research
JF - Circulation research
IS - 4
ER -