Androgen treatment protects mouse liver chromatin from cleavage by endogenous nucleases during aging: Androgen and nuclease activity

S. Mukherjee; A. Asaithambi; M. K. Thakur

doi:10.1007/BF00996306

Androgen treatment protects mouse liver chromatin from cleavage by endogenous nucleases during aging: Androgen and nuclease activity

S. Mukherjee, A. Asaithambi, M. K. Thakur

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

We have examined the endogenous nuclease activity of the liver of intact, castrated and testosterone-treated mice of different ages. Both Mg²⁺- and Ca²⁺-dependent endogenous nuclease activities decline in old age. Withdrawal of the hormone increases nuclease activity in the immature and young. However, testosterone administration prevents the digestion of nuclei to different extents in all ages. These findings suggest a possible protective role of testosterone in the cleavage of liver chromatin by endogenous nucleases during the aging of mice.

Original language	English (US)
Pages (from-to)	59-61
Number of pages	3
Journal	Molecular Biology Reports: An International Journal on Molecular and Cellular Biology
Volume	22
Issue number	1
DOIs	https://doi.org/10.1007/BF00996306
State	Published - Feb 1995

Keywords

aging
androgen
endogenous nuclease
mice liver

ASJC Scopus subject areas

Genetics
Molecular Biology

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10.1007/BF00996306

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Androgen treatment protects mouse liver chromatin from cleavage by endogenous nucleases during aging: Androgen and nuclease activity. / Mukherjee, S.; Asaithambi, A.; Thakur, M. K.
In: Molecular Biology Reports: An International Journal on Molecular and Cellular Biology, Vol. 22, No. 1, 02.1995, p. 59-61.

Research output: Contribution to journal › Article › peer-review

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Androgen treatment protects mouse liver chromatin from cleavage by endogenous nucleases during aging: Androgen and nuclease activity

Abstract

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