TY - JOUR
T1 - And three's a party
T2 - lysosomes, lipid droplets, and the ER in lipid trafficking and cell homeostasis
AU - Henne, Mike
N1 - Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2019/8
Y1 - 2019/8
N2 - Sterols and fatty acids (FAs) are essential lipids that play fundamental roles in membrane dynamics and cellular homeostasis. Synthesized at the endoplasmic reticulum (ER) and cytoplasm, trafficked by proteins, and stored in lipid droplets (LDs), much work has been conducted examining how these lipids are shuttled from one location to another. Recent work has highlighted the importance of inter-organelle crosstalk in the regulation of sterol and FA homeostasis. In particular, three organelles—lysosomes, LDs, and the ER network—function together to regulate sterol subcellular distribution and utilization. This tri-organelle crosstalk also drives adaptions to stress and protects against FA-induced lipotoxicity. Here, we highlight recent work revealing how this unique organelle trio function together. We also discuss how LDs can modulate lysosome signaling to control growth, autophagy, and ER homeostasis.
AB - Sterols and fatty acids (FAs) are essential lipids that play fundamental roles in membrane dynamics and cellular homeostasis. Synthesized at the endoplasmic reticulum (ER) and cytoplasm, trafficked by proteins, and stored in lipid droplets (LDs), much work has been conducted examining how these lipids are shuttled from one location to another. Recent work has highlighted the importance of inter-organelle crosstalk in the regulation of sterol and FA homeostasis. In particular, three organelles—lysosomes, LDs, and the ER network—function together to regulate sterol subcellular distribution and utilization. This tri-organelle crosstalk also drives adaptions to stress and protects against FA-induced lipotoxicity. Here, we highlight recent work revealing how this unique organelle trio function together. We also discuss how LDs can modulate lysosome signaling to control growth, autophagy, and ER homeostasis.
UR - http://www.scopus.com/inward/record.url?scp=85064327032&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85064327032&partnerID=8YFLogxK
U2 - 10.1016/j.ceb.2019.02.011
DO - 10.1016/j.ceb.2019.02.011
M3 - Review article
C2 - 31003052
AN - SCOPUS:85064327032
SN - 0955-0674
VL - 59
SP - 40
EP - 49
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
ER -