ANCA-negative glomerulonephritis associated with nonasthmatic Churg-Strauss syndrome

Asha J. Chemmalakuzhy, Xin J. Zhou, S. Susan Hedayati

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Background: A 36-year-old white male with a history of allergic rhinitis and sinusitis presented to the emergency room with abdominal pain and diarrhea. Physical examination revealed fever, hypoxemia and a maculopapular rash. Laboratory tests showed proteinuria, hematuria, leukocytosis, eosinophilia and an elevated erythrocyte sedimentation rate. Investigations: Physical examination, urine and blood analysis and culture, chest radiography, chest and abdominal CT, esophagogastroduodenoscopy, skin and kidney biopsy, serology and renal ultrasound. Diagnosis: Pauci-immune focal necrotizing glomerulonephritis with crescents and interstitial eosinophilia, consistent with Churg-Strauss syndrome. Management: The patient was treated with methylprednisolone 1 g/day intravenously for 3 days. He also received oral clotrimazole and combined oral sulfamethoxazole and trimethoprim for prophylaxis against candidiasis and pneumonia, respectively. He left the hospital against medical advice and was lost to follow-up.

Original languageEnglish (US)
Pages (from-to)568-574
Number of pages7
JournalNature Clinical Practice Nephrology
Issue number10
StatePublished - Oct 2008


  • Churg-Strauss syndrome
  • Eosinophilia
  • Necrotizing glomerulonephritis
  • Small-vessel vasculitis

ASJC Scopus subject areas

  • Nephrology


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