Anatomy of the cervicomental region: Insights from an anatomy laboratory and roundtable discussion

Jeffrey M. Kenkel, Derek H. Jones, Steven Fagien, Dee Anna Glaser, Gary D. Monheit, Karen Stauffer, Jonathan M. Sykes

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


In 2015, ATX-101 (deoxycholic acid injection; Kybella in the United States and Belkyra in Canada; Kythera Biopharmaceuticals, Inc., Westlake Village, CA [an affiliate of Allergan plc, Dublin, Ireland]) was approved as a first-inclass injectable drug for reduction of submental fat. Use of a pharmacologic/injectable therapy within the submental region requires a thorough understanding of cervicomental anatomy to ensure proper injection technique and safe administration. To this end, an anatomy laboratory was conducted to review key external landmarks and important internal anatomic structures that characterize the lower face and anterior neck. External landmarks that define the boundaries of the cervicomental and submental regions were identified including the inferior mandibular border, the anterior border of the sternocleidomastoid muscle, the antegonial notch, the submental crease, the thyroid notch, and the hyoid bone. Relevant internal anatomic structures, including preplatysmal submental fat (the target tissue for ATX-101) and the platysma muscle as well as critical neurovascular and glandular tissues were revealed by dissection. Of particular interest was the marginal mandibular branch of the facial nerve because it typically courses along the inferior mandibular border near the proposed treatment area for ATX-101.

Original languageEnglish (US)
Pages (from-to)S282-S287
JournalDermatologic Surgery
StatePublished - 2016

ASJC Scopus subject areas

  • Surgery
  • Dermatology


Dive into the research topics of 'Anatomy of the cervicomental region: Insights from an anatomy laboratory and roundtable discussion'. Together they form a unique fingerprint.

Cite this