Anatomy of an enhancer

Catherine C. Thompson; Steven L. McKnight

doi:10.1016/0168-9525(92)90392-H

Anatomy of an enhancer

Catherine C. Thompson, Steven L. McKnight

Research output: Contribution to journal › Review article › peer-review

78 Scopus citations

Abstract

Enhancers, the elements that regulate spatial and temporal gene expression in eukaryotic cells, act as templates for the assembly of multiprotein complexes. Studies on the enhancers associated with immediate-early genes of herpes simplex virus reveal an unanticipated recurrence of specific protein-protein interactions, comparable to a three-dimensional 'jigsaw' puzzle. The arrangement of cis regulatory motifs - the DNA sequence of an enhancer-forms the puzzle template. Specific regulatory proteins, by forming contours of appropriate fit for both DNA template and neighboring proteins, constitute the puzzle pieces.

Original language	English (US)
Pages (from-to)	232-236
Number of pages	5
Journal	Trends in Genetics
Volume	8
Issue number	7
DOIs	https://doi.org/10.1016/0168-9525(92)90392-H
State	Published - Jul 1992

ASJC Scopus subject areas

Genetics

Access to Document

10.1016/0168-9525(92)90392-H

Cite this

@article{0585f4233e88431aa0612342bf289d1a,

title = "Anatomy of an enhancer",

abstract = "Enhancers, the elements that regulate spatial and temporal gene expression in eukaryotic cells, act as templates for the assembly of multiprotein complexes. Studies on the enhancers associated with immediate-early genes of herpes simplex virus reveal an unanticipated recurrence of specific protein-protein interactions, comparable to a three-dimensional 'jigsaw' puzzle. The arrangement of cis regulatory motifs - the DNA sequence of an enhancer-forms the puzzle template. Specific regulatory proteins, by forming contours of appropriate fit for both DNA template and neighboring proteins, constitute the puzzle pieces.",

author = "Thompson, {Catherine C.} and McKnight, {Steven L.}",

year = "1992",

month = jul,

doi = "10.1016/0168-9525(92)90392-H",

language = "English (US)",

volume = "8",

pages = "232--236",

journal = "Trends in Genetics",

issn = "0168-9525",

publisher = "Elsevier Limited",

number = "7",

}

TY - JOUR

T1 - Anatomy of an enhancer

AU - Thompson, Catherine C.

AU - McKnight, Steven L.

PY - 1992/7

Y1 - 1992/7

N2 - Enhancers, the elements that regulate spatial and temporal gene expression in eukaryotic cells, act as templates for the assembly of multiprotein complexes. Studies on the enhancers associated with immediate-early genes of herpes simplex virus reveal an unanticipated recurrence of specific protein-protein interactions, comparable to a three-dimensional 'jigsaw' puzzle. The arrangement of cis regulatory motifs - the DNA sequence of an enhancer-forms the puzzle template. Specific regulatory proteins, by forming contours of appropriate fit for both DNA template and neighboring proteins, constitute the puzzle pieces.

AB - Enhancers, the elements that regulate spatial and temporal gene expression in eukaryotic cells, act as templates for the assembly of multiprotein complexes. Studies on the enhancers associated with immediate-early genes of herpes simplex virus reveal an unanticipated recurrence of specific protein-protein interactions, comparable to a three-dimensional 'jigsaw' puzzle. The arrangement of cis regulatory motifs - the DNA sequence of an enhancer-forms the puzzle template. Specific regulatory proteins, by forming contours of appropriate fit for both DNA template and neighboring proteins, constitute the puzzle pieces.

UR - http://www.scopus.com/inward/record.url?scp=0026637673&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026637673&partnerID=8YFLogxK

U2 - 10.1016/0168-9525(92)90392-H

DO - 10.1016/0168-9525(92)90392-H

M3 - Review article

AN - SCOPUS:0026637673

SN - 0168-9525

VL - 8

SP - 232

EP - 236

JO - Trends in Genetics

JF - Trends in Genetics

IS - 7

ER -

Anatomy of an enhancer

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this