@article{9d91b276911f473795a2912af61b0dd3,
title = "Analysis of the butyrylcholinesterase gene and nearby chromosome 3 markers in Alzheimer disease",
abstract = "The K-variant of butyrylcholinesterase (BCHE-K) recently has been reported to be associated with Alzheimer disease (AD) in carriers of the ε4 allele of the apolipoprotein E (APOE) gene. We have re-examined the frequency of the BCHE-K allele in a large data set of both sporadic and familial cases of AD disease, and we have also examined the segregation of three genetic markers on chromosome 3 near BCHE. Our data neither support an association of BCHE-K with sporadic or familial AD, nor do they suggest the existence of another gene nearby on chromosome 3 as a common cause of familial AD.",
author = "N. Brindle and Y. Song and E. Rogaeva and S. Premkumar and G. Levesque and G. Yu and M. Ikeda and M. Nishimura and A. Paterson and S. Sorbi and R. Duara and L. Farrer and {St George-Hyslop}, P.",
note = "Funding Information: This work was supported through grants from the Medical Research Council of Canada, The Canadian Genetic Diseases Network, The Alzheimer Association of Ontario, The Howard Hughes Medical Research Foundation, the EJLB Foundation, the National Institutes of Health (AG09029), the Peter Burgess Fellowship (E.A.R.), the Alzheimer Society of Canada Fellowship (G.L.), the Helen B. Hunter Fellowship (G.Y.), the National Institutes of Health (T32-AG00115) (S.P.) and the Medical Research Council of Canada (A.P.).",
year = "1998",
month = may,
doi = "10.1093/hmg/7.5.933",
language = "English (US)",
volume = "7",
pages = "933--935",
journal = "Human Molecular Genetics",
issn = "0964-6906",
publisher = "Oxford University Press",
number = "5",
}