Anabolic effects of fluoride on bone

Charles Y C Pak, Joseph E. Zerwekh, Peter Antich

Research output: Contribution to journalArticlepeer-review

67 Scopus citations


Fluoride exerts a biphasic action at the level of osteoblasts, on bone mineral, on bone structure and function, and in the treatment of osteoporosis. At low circulating concentrations, skeletal uptake of fluoride is limited and the effects are beneficial. At higher concentrations and greater skeletal uptake, fluoride may cause the formation of abnormally mineralized bone of impaired quality. A new treatment program entailing intermittent slow release sodium fluoride (SR-NaF) with continuous calcium citrate may capture desirable qualities of fluoride without toxic effects, and be therapeutically efficacious in postmenopausal osteoporosis.

Original languageEnglish (US)
Pages (from-to)229-234
Number of pages6
JournalTrends in Endocrinology and Metabolism
Issue number7
StatePublished - Sep 1995

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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