An unusually “complex” glomerulonephritis

Gabriela Martinez-Zayas; Daniel Savino; Sumit Kumar; Kathryn H. Dao

doi:10.1080/08998280.2022.2073106

An unusually “complex” glomerulonephritis

Gabriela Martinez-Zayas, Daniel Savino, Sumit Kumar, Kathryn H. Dao

Research output: Contribution to journal › Article › peer-review

Abstract

A 53-year-old man with granulomatosis with polyangiitis presented with fever and acute kidney injury with nephrotic-range proteinuria following the second dose of the mRNA COVID-19 vaccine. Renal biopsy revealed an unexpected immune complex-glomerulonephritis (IC-GN) without vasculitis. Further workup found the patient to have HIV that was unmasked following the treatment of IC-GN. This case report explores the possible relationship between COVID-19 vaccines and the immune response in the setting of chronic HIV.

Original language	English (US)
Pages (from-to)	531-533
Number of pages	3
Journal	Baylor University Medical Center Proceedings
Volume	35
Issue number	4
DOIs	https://doi.org/10.1080/08998280.2022.2073106
State	Published - 2022

Keywords

COVID vaccine
glomerulonephritis
granulomatosis with polyangiitis
human immunodeficiency virus
immune complexes
type III hypersensitivity

ASJC Scopus subject areas

Medicine(all)

Access to Document

10.1080/08998280.2022.2073106

Cite this

@article{40566fd3e4e24bb982ac0e4a286b55b8,

title = "An unusually “complex” glomerulonephritis",

abstract = "A 53-year-old man with granulomatosis with polyangiitis presented with fever and acute kidney injury with nephrotic-range proteinuria following the second dose of the mRNA COVID-19 vaccine. Renal biopsy revealed an unexpected immune complex-glomerulonephritis (IC-GN) without vasculitis. Further workup found the patient to have HIV that was unmasked following the treatment of IC-GN. This case report explores the possible relationship between COVID-19 vaccines and the immune response in the setting of chronic HIV.",

keywords = "COVID vaccine, glomerulonephritis, granulomatosis with polyangiitis, human immunodeficiency virus, immune complexes, type III hypersensitivity",

author = "Gabriela Martinez-Zayas and Daniel Savino and Sumit Kumar and Dao, {Kathryn H.}",

note = "Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2022 Baylor University Medical Center.",

year = "2022",

doi = "10.1080/08998280.2022.2073106",

language = "English (US)",

volume = "35",

pages = "531--533",

journal = "Baylor University Medical Center Proceedings",

issn = "0899-8280",

publisher = "Taylor and Francis Ltd.",

number = "4",

}

TY - JOUR

T1 - An unusually “complex” glomerulonephritis

AU - Martinez-Zayas, Gabriela

AU - Savino, Daniel

AU - Kumar, Sumit

AU - Dao, Kathryn H.

PY - 2022

Y1 - 2022

N2 - A 53-year-old man with granulomatosis with polyangiitis presented with fever and acute kidney injury with nephrotic-range proteinuria following the second dose of the mRNA COVID-19 vaccine. Renal biopsy revealed an unexpected immune complex-glomerulonephritis (IC-GN) without vasculitis. Further workup found the patient to have HIV that was unmasked following the treatment of IC-GN. This case report explores the possible relationship between COVID-19 vaccines and the immune response in the setting of chronic HIV.

AB - A 53-year-old man with granulomatosis with polyangiitis presented with fever and acute kidney injury with nephrotic-range proteinuria following the second dose of the mRNA COVID-19 vaccine. Renal biopsy revealed an unexpected immune complex-glomerulonephritis (IC-GN) without vasculitis. Further workup found the patient to have HIV that was unmasked following the treatment of IC-GN. This case report explores the possible relationship between COVID-19 vaccines and the immune response in the setting of chronic HIV.

KW - COVID vaccine

KW - glomerulonephritis

KW - granulomatosis with polyangiitis

KW - human immunodeficiency virus

KW - immune complexes

KW - type III hypersensitivity

UR - http://www.scopus.com/inward/record.url?scp=85130469070&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85130469070&partnerID=8YFLogxK

U2 - 10.1080/08998280.2022.2073106

DO - 10.1080/08998280.2022.2073106

M3 - Article

C2 - 35754562

AN - SCOPUS:85130469070

SN - 0899-8280

VL - 35

SP - 531

EP - 533

JO - Baylor University Medical Center Proceedings

JF - Baylor University Medical Center Proceedings

IS - 4

ER -

An unusually “complex” glomerulonephritis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this