TY - JOUR
T1 - An RNA polymerase II transcription factor shares functional properties with Escherichia coli σ70
AU - Conaway, Joan Weliky
AU - Conaway, Ronald C.
PY - 1990
Y1 - 1990
N2 - A mammalian transcription factor, which, along with other factors, is essential for accurate initiation of transcription from promoters by RNA polymerase II, has been found to regulate the interaction of polymerase and DNA. This factor, designated βγ, drastically reduces the affinity of RNA polymerase II for free DNA containing either promoter or nonpromoter sequences. In this respect, βγ functions as does the bacterial transcription initiation factor σ70, which expedites the binding of Escherichia coli RNA polymerase to promoters in part by accelerating dissociation of the polymerase from nonpromoter sites in DNA.
AB - A mammalian transcription factor, which, along with other factors, is essential for accurate initiation of transcription from promoters by RNA polymerase II, has been found to regulate the interaction of polymerase and DNA. This factor, designated βγ, drastically reduces the affinity of RNA polymerase II for free DNA containing either promoter or nonpromoter sequences. In this respect, βγ functions as does the bacterial transcription initiation factor σ70, which expedites the binding of Escherichia coli RNA polymerase to promoters in part by accelerating dissociation of the polymerase from nonpromoter sites in DNA.
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U2 - 10.1126/science.2193400
DO - 10.1126/science.2193400
M3 - Article
C2 - 2193400
AN - SCOPUS:0025333869
SN - 0036-8075
VL - 248
SP - 1550
EP - 1553
JO - Science
JF - Science
IS - 4962
ER -