An RNA polymerase II elongation factor encoded by the human ELL gene

Ali Shilatifard, William S. Lane, Kenneth W. Jackson, Ronald C. Conaway, Joan W. Conaway

Research output: Contribution to journalArticlepeer-review

286 Scopus citations


The human ELL gene on chromosome 19 undergoes frequent translocations with the trithorax-like MLL gene on chromosome 11 in acute myeloid leukemias. Here, ELL was shown to encode a previously uncharacterized elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by polymerase at multiple sites along the DNA. Functionally, ELL resembles Elongin (Sill), a transcription elongation factor regulated by the product of the von Hippel-Lindau (VHL) tumor suppressor gene. The discovery of a second elongation factor implicated in oncogenesis provides further support for a close connection between the regulation of transcription elongation and cell growth.

Original languageEnglish (US)
Pages (from-to)1873-1876
Number of pages4
Issue number5257
StatePublished - Mar 29 1996
Externally publishedYes

ASJC Scopus subject areas

  • General


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