An Overview of Fractional Exhaled Nitric Oxide and Children with Asthma

Devika R. Rao, Wanda Phipatanakul

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations


Asthma is the most common pediatric chronic disease and is characterized by lung inflammation. Fractional exhaled nitric oxide (FeNO) is thought to reflect the presence of eosinophilic airway inflammation, and is an easy, non-invasive test that has held promise in providing additional objective data. However, not all studies have shown a clinical benefit in the use of FeNO to guide management of asthma in children. This review will describe the results of the most recent studies examining the use of FeNO in the diagnosis and treatment of asthma in infants, preschool-aged children and in school-aged children. It will aid the clinician in providing a clinical context in which FeNO may be most useful in treating pediatric asthma.

Original languageEnglish (US)
Pages (from-to)521-530
Number of pages10
JournalExpert review of clinical immunology
Issue number5
StatePublished - May 3 2016


  • Fractional exhaled nitric oxide
  • infant lung function
  • lung function
  • pediatric asthma
  • sickle cell disease

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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