TY - JOUR
T1 - An outbreak of infectious mononucleosis among the personnel of an outpatient clinic
AU - Ginsburg, Charles M.
AU - Henle, Gertrude
AU - Henle, Werner
N1 - Funding Information:
This study has been supported by research grant CA-04568 and contract NOl-CP-33272 from the National Cancer Institute, U. S. Public Health Serv- '"The technical assistance of Marie Adams, Sheila Kelly and Cretyl Mills is gratefully acknowledged.
PY - 1976/11
Y1 - 1976/11
N2 - During a four-week period, nine current or recent primary Epstein-Barr virus (EBV) infections were identified among 29 staff members of an obstetrics and gynecology outpatient clinic of an air force base hospital by EBV-specific serologic tests; i.e., early detection of IgM antibodies to EB viral capsid antigen (VCA), high titers of IgG antibodies to VCA, presence of antibodies to the D (diffuse) component of the EBV-induced early antigen (EA) complex and initial absence and later development of antibodies to the EBV-associated nuclear antigen (EBNA). Five of these individuals showed classical signs and symptoms of infectious mononucleosis (IM) so that the ratio between overt and silent infections was 1.25:1. All but one of these nine individuals gave positive monospot reactions. Three additional staff members were reported to be monospot-positive, of whom two, with prior histories of IM, had IM-like illnesses during the study period but the results of EBV-specific serologic tests were indicative of infections in the past. The EBV infections were limited to the nurses, corpsmen and administrative personnel, of whom none remained susceptible (antibody negative). The virus did not spread to the medical staff although two of the residents had no antibodies to EBV. The data indicate that under some circumstances IM may be more contagious than usually observed.
AB - During a four-week period, nine current or recent primary Epstein-Barr virus (EBV) infections were identified among 29 staff members of an obstetrics and gynecology outpatient clinic of an air force base hospital by EBV-specific serologic tests; i.e., early detection of IgM antibodies to EB viral capsid antigen (VCA), high titers of IgG antibodies to VCA, presence of antibodies to the D (diffuse) component of the EBV-induced early antigen (EA) complex and initial absence and later development of antibodies to the EBV-associated nuclear antigen (EBNA). Five of these individuals showed classical signs and symptoms of infectious mononucleosis (IM) so that the ratio between overt and silent infections was 1.25:1. All but one of these nine individuals gave positive monospot reactions. Three additional staff members were reported to be monospot-positive, of whom two, with prior histories of IM, had IM-like illnesses during the study period but the results of EBV-specific serologic tests were indicative of infections in the past. The EBV infections were limited to the nurses, corpsmen and administrative personnel, of whom none remained susceptible (antibody negative). The virus did not spread to the medical staff although two of the residents had no antibodies to EBV. The data indicate that under some circumstances IM may be more contagious than usually observed.
KW - Epstein-Barr virus
KW - Infectious mononucleosis
KW - Serology
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U2 - 10.1093/oxfordjournals.aje.a112332
DO - 10.1093/oxfordjournals.aje.a112332
M3 - Article
C2 - 185899
AN - SCOPUS:0017190878
SN - 0002-9262
VL - 104
SP - 571
EP - 575
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
IS - 5
ER -