@article{84b64932bd104f41b106ab21ea8f582b,
title = "An interdisciplinary consensus on the management of brain metastases in patients with renal cell carcinoma",
abstract = "Brain metastases are a challenging manifestation of renal cell carcinoma. We have a limited understanding of brain metastasis tumor and immune biology, drivers of resistance to systemic treatment, and their overall poor prognosis. Current data support a multimodal treatment strategy with radiation treatment and/or surgery. Nonetheless, the optimal approach for the management of brain metastases from renal cell carcinoma remains unclear. To improve patient care, the authors sought to standardize practical management strategies. They performed an unstructured literature review and elaborated on the current management strategies through an international group of experts from different disciplines assembled via the network of the International Kidney Cancer Coalition. Experts from different disciplines were administered a survey to answer questions related to current challenges and unmet patient needs. On the basis of the integrated approach of literature review and survey study results, the authors built algorithms for the management of single and multiple brain metastases in patients with renal cell carcinoma. The literature review, consensus statements, and algorithms presented in this report can serve as a framework guiding treatment decisions for patients. CA Cancer J Clin. 2022;72:000-000.",
keywords = "brain metastases, diagnostic evaluation, immune checkpoint blockers, renal cell carcinoma",
author = "Elshad Hasanov and Yeboa, {Debra Nana} and Tucker, {Mathew D.} and Swanson, {Todd A.} and Beckham, {Thomas Hendrix} and Brian Rini and Ene, {Chibawanye I.} and Merve Hasanov and Sophie Derks and Marion Smits and Shaan Dudani and Heng, {Daniel Y.C.} and Brastianos, {Priscilla K.} and Axel Bex and Sahin Hanalioglu and Weinberg, {Jeffrey S.} and Laure Hirsch and Carlo, {Maria I.} and Ayal Aizer and Brown, {Paul David} and Bilen, {Mehmet Asim} and Chang, {Eric Lin} and Jerry Jaboin and James Brugarolas and Choueiri, {Toni K.} and Atkins, {Michael B.} and McGregor, {Bradley A.} and Halasz, {Lia M.} and Patel, {Toral R.} and Soltys, {Scott G.} and McDermott, {David F.} and Elder, {James Bradley} and Baskaya, {Mustafa K.} and Yu, {James B.} and Robert Timmerman and Kim, {Michelle Miran} and Melike Mut and James Markert and Kathryn Beal and Tannir, {Nizar M.} and George Samandouras and Lang, {Frederick F.} and Rachel Giles and Eric Jonasch",
note = "Funding Information: We thank the International Kidney Cancer Coalition for supporting this consensus-building task force. We thank Sunita Patterson, Senior Scientific Editor, Research Medical Library, The University of Texas MD Anderson Cancer Center, for editing this article. Publisher Copyright: {\textcopyright} 2022 The Authors. CA: A Cancer Journal for Clinicians published by Wiley Periodicals LLC on behalf of American Cancer Society.",
year = "2022",
month = sep,
day = "1",
doi = "10.3322/caac.21729",
language = "English (US)",
journal = "CA Cancer Journal for Clinicians",
issn = "0007-9235",
publisher = "Wiley-Blackwell",
}