An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targets

Karen I. Zeller; Anil G. Jegga; Bruce J. Aronow; Kathryn A O'Donnell-Mendell; Chi V. Dang

doi:10.1186/gb-2003-4-10-r69

An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targets

Karen I. Zeller, Anil G. Jegga, Bruce J. Aronow, Kathryn A O'Donnell-Mendell, Chi V. Dang

Research output: Contribution to journal › Article › peer-review

411 Scopus citations

Abstract

We report a database of genes responsive to the Myc oncogenic transcription factor. The database Myc Target Gene prioritizes candidate target genes according to experimental evidence and clusters responsive genes into functional groups. We coupled the prioritization of target genes with phylogenetic sequence comparisons to predict c-Myc target binding sites, which are in turn validated by chromatin immunoprecipitation assays. This database is essential for the understanding of the genetic regulatory networks underlying the genesis of cancers.

Original language	English (US)
Article number	R69
Journal	Genome biology
Volume	4
Issue number	10
DOIs	https://doi.org/10.1186/gb-2003-4-10-r69
State	Published - Oct 2003

Keywords

Chromatin Immunoprecipitation
DDX18 Gene
Direct Target Gene
Phylogenetic Footprinting
Putative Target Gene

ASJC Scopus subject areas

Genetics
Ecology, Evolution, Behavior and Systematics
Cell Biology

Access to Document

10.1186/gb-2003-4-10-r69

Cite this

@article{186c41c4684d4ce9b495b200e01f3e20,

title = "An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targets",

abstract = "We report a database of genes responsive to the Myc oncogenic transcription factor. The database Myc Target Gene prioritizes candidate target genes according to experimental evidence and clusters responsive genes into functional groups. We coupled the prioritization of target genes with phylogenetic sequence comparisons to predict c-Myc target binding sites, which are in turn validated by chromatin immunoprecipitation assays. This database is essential for the understanding of the genetic regulatory networks underlying the genesis of cancers.",

keywords = "Chromatin Immunoprecipitation, DDX18 Gene, Direct Target Gene, Phylogenetic Footprinting, Putative Target Gene",

author = "Zeller, {Karen I.} and Jegga, {Anil G.} and Aronow, {Bruce J.} and O'Donnell-Mendell, {Kathryn A} and Dang, {Chi V.}",

note = "Publisher Copyright: {\textcopyright} 2003, Zeller et al.; licensee BioMed Central Ltd.",

year = "2003",

month = oct,

doi = "10.1186/gb-2003-4-10-r69",

language = "English (US)",

volume = "4",

journal = "Genome biology",

issn = "1474-7596",

publisher = "BioMed Central",

number = "10",

}

TY - JOUR

T1 - An integrated database of genes responsive to the Myc oncogenic transcription factor

T2 - identification of direct genomic targets

AU - Zeller, Karen I.

AU - Jegga, Anil G.

AU - Aronow, Bruce J.

AU - O'Donnell-Mendell, Kathryn A

AU - Dang, Chi V.

PY - 2003/10

Y1 - 2003/10

N2 - We report a database of genes responsive to the Myc oncogenic transcription factor. The database Myc Target Gene prioritizes candidate target genes according to experimental evidence and clusters responsive genes into functional groups. We coupled the prioritization of target genes with phylogenetic sequence comparisons to predict c-Myc target binding sites, which are in turn validated by chromatin immunoprecipitation assays. This database is essential for the understanding of the genetic regulatory networks underlying the genesis of cancers.

AB - We report a database of genes responsive to the Myc oncogenic transcription factor. The database Myc Target Gene prioritizes candidate target genes according to experimental evidence and clusters responsive genes into functional groups. We coupled the prioritization of target genes with phylogenetic sequence comparisons to predict c-Myc target binding sites, which are in turn validated by chromatin immunoprecipitation assays. This database is essential for the understanding of the genetic regulatory networks underlying the genesis of cancers.

KW - Chromatin Immunoprecipitation

KW - DDX18 Gene

KW - Direct Target Gene

KW - Phylogenetic Footprinting

KW - Putative Target Gene

UR - http://www.scopus.com/inward/record.url?scp=0842278571&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0842278571&partnerID=8YFLogxK

U2 - 10.1186/gb-2003-4-10-r69

DO - 10.1186/gb-2003-4-10-r69

M3 - Article

C2 - 14519204

AN - SCOPUS:0842278571

SN - 1474-7596

VL - 4

JO - Genome biology

JF - Genome biology

IS - 10

M1 - R69

ER -

An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targets

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this