An expanded universe of cancer targets

the Cancer Target Discovery and Development Network

doi:10.1016/j.cell.2021.02.020

An expanded universe of cancer targets

the Cancer Target Discovery and Development Network

Research output: Contribution to journal › Review article › peer-review

107 Scopus citations

Abstract

The characterization of cancer genomes has provided insight into somatically altered genes across tumors, transformed our understanding of cancer biology, and enabled tailoring of therapeutic strategies. However, the function of most cancer alleles remains mysterious, and many cancer features transcend their genomes. Consequently, tumor genomic characterization does not influence therapy for most patients. Approaches to understand the function and circuitry of cancer genes provide complementary approaches to elucidate both oncogene and non-oncogene dependencies. Emerging work indicates that the diversity of therapeutic targets engendered by non-oncogene dependencies is much larger than the list of recurrently mutated genes. Here we describe a framework for this expanded list of cancer targets, providing novel opportunities for clinical translation. Members of the Cancer Target Discovery and Development Network synthesize recent insights into the different classes and characteristics of cancer therapeutic vulnerabilities.

Original language	English (US)
Pages (from-to)	1142-1155
Number of pages	14
Journal	Cell
Volume	184
Issue number	5
DOIs	https://doi.org/10.1016/j.cell.2021.02.020
State	Published - Mar 4 2021

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.cell.2021.02.020

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@article{ab953ecf0b064a118d6a31b79f61314a,

title = "An expanded universe of cancer targets",

abstract = "The characterization of cancer genomes has provided insight into somatically altered genes across tumors, transformed our understanding of cancer biology, and enabled tailoring of therapeutic strategies. However, the function of most cancer alleles remains mysterious, and many cancer features transcend their genomes. Consequently, tumor genomic characterization does not influence therapy for most patients. Approaches to understand the function and circuitry of cancer genes provide complementary approaches to elucidate both oncogene and non-oncogene dependencies. Emerging work indicates that the diversity of therapeutic targets engendered by non-oncogene dependencies is much larger than the list of recurrently mutated genes. Here we describe a framework for this expanded list of cancer targets, providing novel opportunities for clinical translation. Members of the Cancer Target Discovery and Development Network synthesize recent insights into the different classes and characteristics of cancer therapeutic vulnerabilities.",

author = "{the Cancer Target Discovery and Development Network} and Hahn, {William C.} and Bader, {Joel S.} and Braun, {Theodore P.} and Andrea Califano and Clemons, {Paul A.} and Druker, {Brian J.} and Ewald, {Andrew J.} and Haian Fu and Subhashini Jagu and Kemp, {Christopher J.} and William Kim and Kuo, {Calvin J.} and Michael McManus and {B. Mills}, Gordon and Xiulei Mo and Nidhi Sahni and Schreiber, {Stuart L.} and Talamas, {Jessica A.} and Pablo Tamayo and Tyner, {Jeffrey W.} and Wagner, {Bridget K.} and Weiss, {William A.} and Gerhard, {Daniela S.} and Vlado Dancik and Shubhroz Gill and Bruce Hua and Tanaz Sharifnia and Vasanthi Viswanathan and Yilong Zou and {Dela Cruz}, Filemon and Andrew Kung and Brent Stockwell and Jesse Boehm and Josh Dempster and Robert Manguso and Francisca Vazquez and Cooper, {Lee A.D.} and Yuhong Du and Andrey Ivanov and Sagar Lonial and Moreno, {Carlos S.} and Qiankun Niu and Taofeek Owonikoko and Suresh Ramalingam and Matthew Reyna and Wei Zhou and Carla Grandori and Ilya Shmulevich and Elizabeth Swisher and Chan, {Issac S.}",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",

year = "2021",

month = mar,

day = "4",

doi = "10.1016/j.cell.2021.02.020",

language = "English (US)",

volume = "184",

pages = "1142--1155",

journal = "Cell",

issn = "0092-8674",

publisher = "Cell Press",

number = "5",

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T1 - An expanded universe of cancer targets

AU - the Cancer Target Discovery and Development Network

AU - Hahn, William C.

AU - Bader, Joel S.

AU - Braun, Theodore P.

AU - Califano, Andrea

AU - Clemons, Paul A.

AU - Druker, Brian J.

AU - Ewald, Andrew J.

AU - Fu, Haian

AU - Jagu, Subhashini

AU - Kemp, Christopher J.

AU - Kim, William

AU - Kuo, Calvin J.

AU - McManus, Michael

AU - B. Mills, Gordon

AU - Mo, Xiulei

AU - Sahni, Nidhi

AU - Schreiber, Stuart L.

AU - Talamas, Jessica A.

AU - Tamayo, Pablo

AU - Tyner, Jeffrey W.

AU - Wagner, Bridget K.

AU - Weiss, William A.

AU - Gerhard, Daniela S.

AU - Dancik, Vlado

AU - Gill, Shubhroz

AU - Hua, Bruce

AU - Sharifnia, Tanaz

AU - Viswanathan, Vasanthi

AU - Zou, Yilong

AU - Dela Cruz, Filemon

AU - Kung, Andrew

AU - Stockwell, Brent

AU - Boehm, Jesse

AU - Dempster, Josh

AU - Manguso, Robert

AU - Vazquez, Francisca

AU - Cooper, Lee A.D.

AU - Du, Yuhong

AU - Ivanov, Andrey

AU - Lonial, Sagar

AU - Moreno, Carlos S.

AU - Niu, Qiankun

AU - Owonikoko, Taofeek

AU - Ramalingam, Suresh

AU - Reyna, Matthew

AU - Zhou, Wei

AU - Grandori, Carla

AU - Shmulevich, Ilya

AU - Swisher, Elizabeth

AU - Chan, Issac S.

PY - 2021/3/4

Y1 - 2021/3/4

N2 - The characterization of cancer genomes has provided insight into somatically altered genes across tumors, transformed our understanding of cancer biology, and enabled tailoring of therapeutic strategies. However, the function of most cancer alleles remains mysterious, and many cancer features transcend their genomes. Consequently, tumor genomic characterization does not influence therapy for most patients. Approaches to understand the function and circuitry of cancer genes provide complementary approaches to elucidate both oncogene and non-oncogene dependencies. Emerging work indicates that the diversity of therapeutic targets engendered by non-oncogene dependencies is much larger than the list of recurrently mutated genes. Here we describe a framework for this expanded list of cancer targets, providing novel opportunities for clinical translation. Members of the Cancer Target Discovery and Development Network synthesize recent insights into the different classes and characteristics of cancer therapeutic vulnerabilities.

AB - The characterization of cancer genomes has provided insight into somatically altered genes across tumors, transformed our understanding of cancer biology, and enabled tailoring of therapeutic strategies. However, the function of most cancer alleles remains mysterious, and many cancer features transcend their genomes. Consequently, tumor genomic characterization does not influence therapy for most patients. Approaches to understand the function and circuitry of cancer genes provide complementary approaches to elucidate both oncogene and non-oncogene dependencies. Emerging work indicates that the diversity of therapeutic targets engendered by non-oncogene dependencies is much larger than the list of recurrently mutated genes. Here we describe a framework for this expanded list of cancer targets, providing novel opportunities for clinical translation. Members of the Cancer Target Discovery and Development Network synthesize recent insights into the different classes and characteristics of cancer therapeutic vulnerabilities.

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UR - http://www.scopus.com/inward/citedby.url?scp=85101808521&partnerID=8YFLogxK

U2 - 10.1016/j.cell.2021.02.020

DO - 10.1016/j.cell.2021.02.020

M3 - Review article

C2 - 33667368

AN - SCOPUS:85101808521

SN - 0092-8674

VL - 184

SP - 1142

EP - 1155

JO - Cell

JF - Cell

IS - 5

ER -

An expanded universe of cancer targets

Abstract

ASJC Scopus subject areas

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