An expanded universe of cancer targets

the Cancer Target Discovery and Development Network

Research output: Contribution to journalReview articlepeer-review

104 Scopus citations


The characterization of cancer genomes has provided insight into somatically altered genes across tumors, transformed our understanding of cancer biology, and enabled tailoring of therapeutic strategies. However, the function of most cancer alleles remains mysterious, and many cancer features transcend their genomes. Consequently, tumor genomic characterization does not influence therapy for most patients. Approaches to understand the function and circuitry of cancer genes provide complementary approaches to elucidate both oncogene and non-oncogene dependencies. Emerging work indicates that the diversity of therapeutic targets engendered by non-oncogene dependencies is much larger than the list of recurrently mutated genes. Here we describe a framework for this expanded list of cancer targets, providing novel opportunities for clinical translation. Members of the Cancer Target Discovery and Development Network synthesize recent insights into the different classes and characteristics of cancer therapeutic vulnerabilities.

Original languageEnglish (US)
Pages (from-to)1142-1155
Number of pages14
Issue number5
StatePublished - Mar 4 2021

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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