TY - JOUR
T1 - An Association Between the Inflammatory Biomarker GlycA and Depressive Symptom Severity
AU - Huckvale, Samara
AU - Reyes, Stephanie
AU - Kulikova, Alexandra
AU - Rohatgi, Anand
AU - Riggs, Kayla A.
AU - Brown, E. Sherwood
N1 - Funding Information:
Publishedonline:November 17, 2020. 12. Matthews KA, Schott LL, Bromberger JT, et al. Assoc. 2014;3(5):e001221.PubMed CrossRef Potential conflicts of interest:Dr Brownhas Are there bi-directional associations between Chen X, Ender P, Wells C. SPSS Web Books ongoing or recent research funding from the depressive symptoms and C-reactive protein in Regression with SPSS. Institute for Digital NationalInstituteofMentalHealth;theNational mid-life women? Brain Behav Immun. Research and Education website. https://stats. Institute on Alcohol Abuse and Alcoholism; the 2010;24(1):96–101.PubMed CrossRef idre.ucla.edu/spss/webbooks/reg/. 2003. NationalInstituteonAging;theNationalHeart, 13. Cepeda MS, Stang P, Makadia R. Depression is IBM SPSS Statistics for Windows, version 24.0 Lung, and Blood Institute (NHLBI); the National associated with high levels of C-reactive [computer program]. Armonk, NY: IBM Corp; Center for Complementary and Integrative Health; protein and low levels of fractional exhaled 2016. nitric oxide: results from the 2007–2012 Paschall MJ, Freisthler B, Lipton RI. Moderate NationalHealthandNutritionExaminationtheStanleyMedicalResearchInstitute;andOtsuka alcohol use and depression in young adults: Surveys. J Clin Psychiatry. Pharmaceuticals and serves on an advisory board findings from a national longitudinal study. 2016;77(12):1666–1671.PubMedCrossRefforAllergan.DrRohatgihas ongoing or recent Am J Public Health. 2005;95(3):453–457.PubMed CrossRef Tayefi M, Shafiee M, Kazemi-Bajestani SMR, et research funding from the National Institutes of 31. Bellos S, Skapinakis P, Rai D, et al. Longitudinal Health (NIH), NHLBI, and Merck and served as al. Depression and anxiety both associate with association between different levels of alcohol consultant to CSL Limited and on an advisory board serum level of hs-CRP: a gender-stratified consumption and a new onset of depression analysisinapopulation-basedstudy.for HDL Diagnostics. DrRiggsand MssHuckvale, and generalized anxiety disorder: results from Reyes, and Kulikovahave no potential conflicts of Psychoneuroendocrinology. 2017;81:63–69.PubMed CrossRef an international study in primary care. interesttodeclare.15.Valkanova V, Ebmeier KP, Allan CL. CRP, IL-6 and PsychiatryRes.2016;243:30–34.PubMedCrossRef Funding/support: This work was supported, in depression: a systematic review and meta- Gea A, Martinez-Gonzalez MA, Toledo E, et al. part, by the Science Teacher Access to Resources analysis of longitudinal studies. J Affect Disord. A longitudinal assessment of alcohol intake at Southwestern (STARS) program, the National 2013;150(3):736–744.PubMed CrossRef and incident depression: the SUN project. BMC Center for Advancing Translational Sciences of Almeida OP, Norman P, Hankey GJ, et al. The Public Health. 2012;12(1):954.PubMed CrossRef the NIH under award number [UL1TR001105], and association between C-reactive protein Haynes JC, Farrell M, Singleton N, et al. Alcohol the Donald W. Reynolds Cardiovascular Clinical concentration and depression in later life is consumption as a risk factor for anxiety and Research Center. due to poor physical health: results from the depression: results from the longitudinal Role of the sponsor: The supporters had no role in Health in Men Study (HIMS). Psychol Med. follow-up of the National Psychiatric the design, analysis, interpretation, or publication 2007;37(12):1775–1786.PubMed CrossRefMorbidity Survey. Br J Psychiatry. ofthisstudy. 17. de Menezes ST, de Figueiredo RC, Goulart AC, 2005;187(6):544–551.PubMed CrossRef Disclaimer: The content is solely the responsibility et al. Lack of association between depression Williams DR, González HM, Neighbors H, et al. of the authors and does not necessarily represent and C-reactive protein level in the baseline of Prevalence and distribution of major the official views of the NIH. Longitudinal Study of Adult Health (ELSA-depressive disorder in African Americans, Brasil). J Affect Disord. 2017;208:448–454.PubMed CrossRef results from the National Survey of American Caribbeanblacks,andnon-Hispanic whites:
Funding Information:
This work was supported, in part, by the Science Teacher Access to Resources at Southwestern (STARS) program, the National Center for Advancing Translational Sciences of the NIH under award number [UL1TR001105], and the Donald W. Reynolds Cardiovascular Clinical Research Center.
Publisher Copyright:
© Copyright 2020 Physicians Postgraduate Press, Inc.
PY - 2021/1
Y1 - 2021/1
N2 - Objective: The underlying mechanisms of depression remain unclear; however, current literature suggests a relationship between inflammation and depression. The association between the inflammatory biomarker high-sensitivity C-reactive protein (hs-CRP) and depression has been previously investigated, but the relationship between GlycA, a novel spectroscopic inflammatory biomarker, and depression does not appear to have been examined. Methods: Data were obtained from The Dallas Heart Study (DHS, conducted between 2000 and 2002), which consisted of a large community-based sample of Dallas County residents (N = 3,033). Depressive symptom severity was assessed with the Quick Inventory of Depressive Symptomatology-Self-Report (QIDS-SR). It was hypothesized that the serum GlycA level would be a statistically significant predictor of QIDS-SR scores after control for demographic covariates. Multiple linear regression was used to assess the relationship between GlycA level and QIDS-SR scores. The role of hs-CRP in predicting QIDS-SR scores was also explored. Results: GlycA level was a statistically significant positive predictor of QIDS-SR score (β = .053, P = .038) with control for sex, age, antidepressant use, ethnicity, smoking status, drinking status, body mass index, and years of education. In a subset of adults with moderate-to-severe depression, GlycA level was not associated with QIDS-SR scores. Additionally, hs-CRP level was not a statistically significant predictor of QIDS-SR scores. Conclusions: This study found a positive association between the inflammatory biomarker GlycA, but not hs-CRP, and depressive symptom severity in a large multiethnic and multiracial community-based sample. Thus, these results provide the first indication that GlycA may be a potentially useful novel biomarker of depression.
AB - Objective: The underlying mechanisms of depression remain unclear; however, current literature suggests a relationship between inflammation and depression. The association between the inflammatory biomarker high-sensitivity C-reactive protein (hs-CRP) and depression has been previously investigated, but the relationship between GlycA, a novel spectroscopic inflammatory biomarker, and depression does not appear to have been examined. Methods: Data were obtained from The Dallas Heart Study (DHS, conducted between 2000 and 2002), which consisted of a large community-based sample of Dallas County residents (N = 3,033). Depressive symptom severity was assessed with the Quick Inventory of Depressive Symptomatology-Self-Report (QIDS-SR). It was hypothesized that the serum GlycA level would be a statistically significant predictor of QIDS-SR scores after control for demographic covariates. Multiple linear regression was used to assess the relationship between GlycA level and QIDS-SR scores. The role of hs-CRP in predicting QIDS-SR scores was also explored. Results: GlycA level was a statistically significant positive predictor of QIDS-SR score (β = .053, P = .038) with control for sex, age, antidepressant use, ethnicity, smoking status, drinking status, body mass index, and years of education. In a subset of adults with moderate-to-severe depression, GlycA level was not associated with QIDS-SR scores. Additionally, hs-CRP level was not a statistically significant predictor of QIDS-SR scores. Conclusions: This study found a positive association between the inflammatory biomarker GlycA, but not hs-CRP, and depressive symptom severity in a large multiethnic and multiracial community-based sample. Thus, these results provide the first indication that GlycA may be a potentially useful novel biomarker of depression.
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U2 - 10.4088/JCP.20M13245
DO - 10.4088/JCP.20M13245
M3 - Article
C2 - 33211910
AN - SCOPUS:85096457948
SN - 0160-6689
VL - 82
JO - Journal of Clinical Psychiatry
JF - Journal of Clinical Psychiatry
IS - 1
M1 - 20M13245
ER -