The biosynthesis of dimeric pyrrole-imidazole alkaloids is likely mediated by enzyme-catalyzed reversible single-electron transfer (SET) cycloaddition. We now show that Ir(ppy)3 can promote SET-mediated formal [2+2] and [4+2] cycloaddition reactions of pyrrole-imidazole alkaloids-related substrates under photolytic conditions. This biomimetic approach is useful for the construction of the core skeleton of nakamuric acid and sceptrin.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Jun 3 2015|
- Single-electron transfer
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry