An approach for the synthesis of nakamuric acid

Xiaolei Wang, Chuo Chen

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


The biosynthesis of dimeric pyrrole-imidazole alkaloids is likely mediated by enzyme-catalyzed reversible single-electron transfer (SET) cycloaddition. We now show that Ir(ppy)3 can promote SET-mediated formal [2+2] and [4+2] cycloaddition reactions of pyrrole-imidazole alkaloids-related substrates under photolytic conditions. This biomimetic approach is useful for the construction of the core skeleton of nakamuric acid and sceptrin.

Original languageEnglish (US)
Pages (from-to)3690-3693
Number of pages4
Issue number22
StatePublished - Jun 3 2015


  • Cyclization
  • Imidazole
  • Pyrrole
  • Radical
  • Single-electron transfer

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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