An analysis of potential biases in the loss of indigent infants to follow-up

Jon E. Tyson, Robert E. Lasky, Charles R. Rosenfeld, Sharon Dowling, Norman Gant

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Loss to follow-up is a major problem in indigent inner-city populations. We evaluated a large, well-described, inborn indigent population of high-risk infants (HRI) and control infants (CI) to assess possible selection biases in loss to follow up at one year adjusted age. Serial clinic visits, phone calls, and letters and payment of $20.00 for attending at 1 year was used to minimize patient loss. Yet, the 1 year loss rate was high, and among HRI, greater for ventilator-treated infants > 1500 g birthweight ( 71 114; 62%) than for ventilator-treated very-low birthweight (VLBW; < 1500 g) infants ( 39 108; 36%) or non-ventilated VLBW infants ( 62 145; 43%) (P < 0.05). Multivariate analyses indicated that those lost to follow-up were at no greater risk of a poor outcome on the basis of prenatal and perinatal medical and socioeconomic findings than were those in the same risk group (HRI or CI) or subgroup of HRI who were examined at 1 year. In a review of hospital records, similar rates of hospitalization and neurologic problems during infancy were identified for HRI examined and HRI lost to follow-up. The identification of such morbidity during infancy may be less complete for HRI lost to follow-up than for those examined. Thus, the high frequency of deficits observed in follow-up evaluation of indigent HRI is unlikely to result from loss of unaffected infants.

Original languageEnglish (US)
Pages (from-to)13-25
Number of pages13
JournalEarly Human Development
Issue number1
StatePublished - Jan 1988


  • follow-up evaluation
  • infant development
  • neonatal intensive care
  • selection biases

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology


Dive into the research topics of 'An analysis of potential biases in the loss of indigent infants to follow-up'. Together they form a unique fingerprint.

Cite this