TY - JOUR
T1 - Amphotericin b tolerance
T2 - A characteristic of candida parapsilosis not shared by other candida species
AU - Seidenfeld, S. M.
AU - Cooper, B. H.
AU - Smith, J. W.
AU - Luby, J. P.
AU - Mackowiak, P. A.
N1 - Funding Information:
Received for publication June 28, 1982. This work was supported in part by funds from the Veterans Administration. We thank Margaret Marling-Cason and Pam Wilkendorf for technical assistance, Michele Steigleder for statistical analysis, and Dr. and Mrs. Hugh H. Hussey for editorial advice. Please address requests for reprints to Dr. Philip A. Mackowiak, Medical Service, V.A. Medical Center, 4500 South Lancaster Drive, Dallas, Texas 75216.
PY - 1983
Y1 - 1983
N2 - Thirty yeast isolates from clinical specimens were tested for their susceptibility to amphotericin B at 30 C, 37 C, and 39 C. Of the six Candida albicans, five Candida tropicalis, one Candida guilliermondii, one Candida krusei, one Candida pseudotropicalis, two Torulopsis glabrata, and four Cryptococcus neojormans isolates tested, all were inhibited at amphotericin B concentrations of ⩽0.4 JJg/ml and killed by concentrations of amphotericin B that were ⩽ 16-fold higher than the minimal inhibitory concentration (MIC). Although growth of Candida parapsilosis was also inhibited by concentrations of amphotericin B of ⩽0.4 µg/ml, minimal fungicidal concentrations of amphotericin B were ⩾32-fold higher than MICs for each of the 10 isolates examined. This unique susceptibility pattern of C. parapsilosis resembles the antibiotic tolerance observed with Staphylococcus aureus. Variations in temperature within the experimental range did not affect the amphotericin B susceptibility for any of the yeasts examined.
AB - Thirty yeast isolates from clinical specimens were tested for their susceptibility to amphotericin B at 30 C, 37 C, and 39 C. Of the six Candida albicans, five Candida tropicalis, one Candida guilliermondii, one Candida krusei, one Candida pseudotropicalis, two Torulopsis glabrata, and four Cryptococcus neojormans isolates tested, all were inhibited at amphotericin B concentrations of ⩽0.4 JJg/ml and killed by concentrations of amphotericin B that were ⩽ 16-fold higher than the minimal inhibitory concentration (MIC). Although growth of Candida parapsilosis was also inhibited by concentrations of amphotericin B of ⩽0.4 µg/ml, minimal fungicidal concentrations of amphotericin B were ⩾32-fold higher than MICs for each of the 10 isolates examined. This unique susceptibility pattern of C. parapsilosis resembles the antibiotic tolerance observed with Staphylococcus aureus. Variations in temperature within the experimental range did not affect the amphotericin B susceptibility for any of the yeasts examined.
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U2 - 10.1093/infdis/147.1.116
DO - 10.1093/infdis/147.1.116
M3 - Article
C2 - 6822746
AN - SCOPUS:0020680955
SN - 0022-1899
VL - 147
SP - 116
EP - 119
JO - The Journal of infectious diseases
JF - The Journal of infectious diseases
IS - 1
ER -