Amphetamine and other pharmacological agents in human and animal studies of recovery from stroke

D. Walker-Batson, J. Mehta, P. Smith, M. Johnson

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Neuromodulation with pharmacological agents, including drugs of abuse such as amphetamine, when paired with behavioral experience, has been shown to positively modify outcomes in animal models of stroke. A number of clinical studies have tested the efficacy of a variety of drugs to enhance recovery of language deficit post-stroke. The purpose of this paper is to: (1) present pertinent animal studies supporting the use of dextro-amphetamine sulfate (AMPH) to enhance recovery after experimental lesions with emphasis on the importance of learning dependent activity for lasting recovery; (2) briefly review neuropharmacological explorations in the treatment of aphasia; (3) present a pilot study in aphasia exploring a drug combination of AMPH and donepezil hydrochloride paired with behavioral treatment to facilitate recovery; and (4) conclude with comments regarding the role of adjunctive pharmacotherapy in the rehabilitation of aphasia, particularly AMPH.

Original languageEnglish (US)
Pages (from-to)225-230
Number of pages6
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
StatePublished - Jan 4 2016


  • Amphetamine
  • Aphasia
  • Clinical trials
  • Neuromodulation
  • Stroke rehabilitation

ASJC Scopus subject areas

  • Pharmacology
  • Biological Psychiatry


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