Abstract
Neuromodulation with pharmacological agents, including drugs of abuse such as amphetamine, when paired with behavioral experience, has been shown to positively modify outcomes in animal models of stroke. A number of clinical studies have tested the efficacy of a variety of drugs to enhance recovery of language deficit post-stroke. The purpose of this paper is to: (1) present pertinent animal studies supporting the use of dextro-amphetamine sulfate (AMPH) to enhance recovery after experimental lesions with emphasis on the importance of learning dependent activity for lasting recovery; (2) briefly review neuropharmacological explorations in the treatment of aphasia; (3) present a pilot study in aphasia exploring a drug combination of AMPH and donepezil hydrochloride paired with behavioral treatment to facilitate recovery; and (4) conclude with comments regarding the role of adjunctive pharmacotherapy in the rehabilitation of aphasia, particularly AMPH.
Original language | English (US) |
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Pages (from-to) | 225-230 |
Number of pages | 6 |
Journal | Progress in Neuro-Psychopharmacology and Biological Psychiatry |
Volume | 64 |
DOIs | |
State | Published - Jan 4 2016 |
Keywords
- Amphetamine
- Aphasia
- Clinical trials
- Neuromodulation
- Stroke rehabilitation
ASJC Scopus subject areas
- Pharmacology
- Biological Psychiatry