Amide-directed tandem C-C/C-N bond formation through C-H activation

Chen Zhu, Rui Wang, J R Falck

Research output: Contribution to journalReview articlepeer-review

250 Scopus citations


The transformation of C-H bonds into other chemical bonds is of great significance in synthetic chemistry. C-H bond-activation processes provide a straightforward and atom-economic strategy for the construction of complex structures; as such, they have attracted widespread interest over the past decade. As a prevalent directing group in the field of C-H activation, the amide group not only offers excellent regiodirecting ability, but is also a potential C-N bond precursor. As a consequence, a variety of nitrogen-containing heterocycles have been obtained by using these reactions. This Focus Review addresses the recent research into the amide-directed tandem C-C/C-N bond-formation process through C-H activation. The large body of research in this field over the past three years has established it as one of the most-important topics in organic chemistry.

Original languageEnglish (US)
Pages (from-to)1502-1514
Number of pages13
JournalChemistry - An Asian Journal
Issue number7
StatePublished - Jun 2012


  • C-C/C-N bond formation
  • C-H activation
  • amides
  • annulation
  • heterocycles

ASJC Scopus subject areas

  • General Chemistry
  • Biochemistry
  • Organic Chemistry


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