Abstract
The α subunit of the guanine nucleotide-binding protein Go ("o" for other) is believed to mediate signal transduction between a variety of receptors and effectors. cDNA clones encoding two forms of Go α subunit were isolated from a mouse brain library. These two forms, which we call GoAα and GoBα, appear to be the products of alternative splicing. GoAα differs from GoBα over the C-terminal third of the deduced protein sequence. Both forms are predicted to be substrates for ADP-ribosylation by pertussis toxin. GoAα transcripts are present in a variety of tissues but are most abundant in brain. The GoBα transcript is expressed at highest levels in brain and testis. It is possible that GoAα and GoBα have different functions.
Original language | English (US) |
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Pages (from-to) | 6477-6481 |
Number of pages | 5 |
Journal | Proceedings of the National Academy of Sciences of the United States of America |
Volume | 87 |
Issue number | 17 |
State | Published - Sep 1990 |
Keywords
- Guanine nucleotide-binding protein
- Signal transduction
ASJC Scopus subject areas
- General