The oxidative Heck arylation of homoallylic alcohols affords adducts in good yields and regioselectivities owing largely to coordination between the catalyst and hydroxy group (see scheme). Moreover, the Heck intermediate can be intercepted by an intramolecular palladium-catalyzed olefin oxyannulation, thus leading to a wide range of α-aryltetrahydrofurans, including highly functionalized scaffolds.
|Original language||English (US)|
|Number of pages||4|
|Journal||Angewandte Chemie - International Edition|
|State||Published - Jul 11 2011|
- homogeneous catalysis
- olefin functionalization
ASJC Scopus subject areas