Altered T-lymphocyte subsets in hospitalized intravenous drug abusers

J. Layon, A. Idris, M. Warzynski, R. Sherer, D. Brauner, O. Patch, D. McCulley, P. Orris

Research output: Contribution to journalArticlepeer-review


Baseline immunologic abnormalities were identified in 16 hospitalized intravenous drug abusers (IDAs) without acquired immune deficiency syndrome (AIDS). Twelve (75%) of 16 had inverted helper-suppressor ratios. In seven patients (44%), the abnormal ratio resulted from an increase in the absolute number of suppressor cells with a normal number of helper T lymphocytes. In five patients (31%), the reduced ratio resulted primarily from decreased helper cells, immunophenotypic findings similar to those seen in patients with AIDS. These findings are similar to what has been noted in other groups at risk for AIDS. Longitudinal follow-up as well as studies of 'healthy' IDAs are required to understand the prognostic implications of these data.

Original languageEnglish (US)
Pages (from-to)1376-1380
Number of pages5
JournalArchives of Internal Medicine
Issue number7
StatePublished - 1984

ASJC Scopus subject areas

  • Internal Medicine


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