Altered T-Lymphocyte Subsets in Hospitalized Intravenous Drug Abusers

Joseph Layon; Ahamed Idris; Michael Warzynski; Renslow Sherer; Daniel Brauner; Olivia Patch; Dorris McCulley; Peter Orris

doi:10.1001/archinte.1984.00350190060011

Altered T-Lymphocyte Subsets in Hospitalized Intravenous Drug Abusers

Joseph Layon, Ahamed Idris, Michael Warzynski, Renslow Sherer, Daniel Brauner, Olivia Patch, Dorris McCulley, Peter Orris

Research output: Contribution to journal › Article › peer-review

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Abstract

Baseline immunologic abnormalities were identified in 16 hospitalized intravenous drug abusers (IDAs) without acquired immune deficiency syndrome (AIDS). Twelve (75%) of 16 had inverted helper-suppressor ratios. In seven patients (44%), the abnormal ratio resulted from an increase in the absolute number of suppressor cells with a normal number of helper T lymphocytes. In five patients (31%), the reduced ratio resulted primarily from decreased helper cells, immunophenotypic findings similar to those seen in patients with AIDS. These findings are similar to what has been noted in other groups at risk for AIDS. Longitudinal follow-up as well as studies of "healthy" IDAs are required to understand the prognostic implications of these data.

Original language	English (US)
Pages (from-to)	1376-1380
Number of pages	5
Journal	Archives of Internal Medicine
Volume	144
Issue number	7
DOIs	https://doi.org/10.1001/archinte.1984.00350190060011
State	Published - Jul 1984

ASJC Scopus subject areas

Internal Medicine

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AU - Warzynski, Michael

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AU - Brauner, Daniel

AU - Patch, Olivia

AU - McCulley, Dorris

AU - Orris, Peter

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AB - Baseline immunologic abnormalities were identified in 16 hospitalized intravenous drug abusers (IDAs) without acquired immune deficiency syndrome (AIDS). Twelve (75%) of 16 had inverted helper-suppressor ratios. In seven patients (44%), the abnormal ratio resulted from an increase in the absolute number of suppressor cells with a normal number of helper T lymphocytes. In five patients (31%), the reduced ratio resulted primarily from decreased helper cells, immunophenotypic findings similar to those seen in patients with AIDS. These findings are similar to what has been noted in other groups at risk for AIDS. Longitudinal follow-up as well as studies of "healthy" IDAs are required to understand the prognostic implications of these data.

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Altered T-Lymphocyte Subsets in Hospitalized Intravenous Drug Abusers

Abstract

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