TY - JOUR
T1 - Altered Aortic Hemodynamics and Relative Pressure in Patients with Dilated Cardiomyopathy
AU - Marlevi, David
AU - Mariscal-Harana, Jorge
AU - Burris, Nicholas S.
AU - Sotelo, Julio
AU - Ruijsink, Bram
AU - Hadjicharalambous, Myrianthi
AU - Asner, Liya
AU - Sammut, Eva
AU - Chabiniok, Radomir
AU - Uribe, Sergio
AU - Winter, Reidar
AU - Lamata, Pablo
AU - Alastruey, Jordi
AU - Nordsletten, David
N1 - Publisher Copyright:
© 2021, The Author(s).
PY - 2022/8
Y1 - 2022/8
N2 - Ventricular-vascular interaction is central in the adaptation to cardiovascular disease. However, cardiomyopathy patients are predominantly monitored using cardiac biomarkers. The aim of this study is therefore to explore aortic function in dilated cardiomyopathy (DCM). Fourteen idiopathic DCM patients and 16 controls underwent cardiac magnetic resonance imaging, with aortic relative pressure derived using physics-based image processing and a virtual cohort utilized to assess the impact of cardiovascular properties on aortic behaviour. Subjects with reduced left ventricular systolic function had significantly reduced aortic relative pressure, increased aortic stiffness, and significantly delayed time-to-pressure peak duration. From the virtual cohort, aortic stiffness and aortic volumetric size were identified as key determinants of aortic relative pressure. As such, this study shows how advanced flow imaging and aortic hemodynamic evaluation could provide novel insights into the manifestation of DCM, with signs of both altered aortic structure and function derived in DCM using our proposed imaging protocol. Graphic Abstractr: [Figure not available: see fulltext.]
AB - Ventricular-vascular interaction is central in the adaptation to cardiovascular disease. However, cardiomyopathy patients are predominantly monitored using cardiac biomarkers. The aim of this study is therefore to explore aortic function in dilated cardiomyopathy (DCM). Fourteen idiopathic DCM patients and 16 controls underwent cardiac magnetic resonance imaging, with aortic relative pressure derived using physics-based image processing and a virtual cohort utilized to assess the impact of cardiovascular properties on aortic behaviour. Subjects with reduced left ventricular systolic function had significantly reduced aortic relative pressure, increased aortic stiffness, and significantly delayed time-to-pressure peak duration. From the virtual cohort, aortic stiffness and aortic volumetric size were identified as key determinants of aortic relative pressure. As such, this study shows how advanced flow imaging and aortic hemodynamic evaluation could provide novel insights into the manifestation of DCM, with signs of both altered aortic structure and function derived in DCM using our proposed imaging protocol. Graphic Abstractr: [Figure not available: see fulltext.]
KW - 4D flow MRI
KW - Aortic hemodynamics
KW - Aortic relative pressure
KW - Aortic stiffness
KW - Dilated cardiomyopathy
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U2 - 10.1007/s12265-021-10181-1
DO - 10.1007/s12265-021-10181-1
M3 - Article
C2 - 34882286
AN - SCOPUS:85128497866
SN - 1937-5387
VL - 15
SP - 692
EP - 707
JO - Journal of cardiovascular translational research
JF - Journal of cardiovascular translational research
IS - 4
ER -