TY - JOUR
T1 - Alterations in the rate of hemoglobin synthesis during chick embryogenesis
AU - Grinnell, F.
AU - Lee, J. C.
PY - 1972/2
Y1 - 1972/2
N2 - The rate of synthesis of different hemoglobin (Hb) species — embryonic, primitive, definitive, and adult — in the circulating red cells of the chick embryo have been measured. On the fifth day of chick embryogenesis, there is a marked decrease in the capability of these red cells to synthesize Hb. The rates of synthesis of embryonic and primitive Hb decrease markedly compared to that of definitive and adult Hb. On the fourth day of embryogenesis nucleic acid synthesis drops sharply in these cells. These decreases in metabolic activity preceed the disappearance of the primitive erythrocyte from the chick embryo circulation. It appears that the primitive cell line is specifically shut off with respect to its metabolic activities and possibly destroyed at this time.
AB - The rate of synthesis of different hemoglobin (Hb) species — embryonic, primitive, definitive, and adult — in the circulating red cells of the chick embryo have been measured. On the fifth day of chick embryogenesis, there is a marked decrease in the capability of these red cells to synthesize Hb. The rates of synthesis of embryonic and primitive Hb decrease markedly compared to that of definitive and adult Hb. On the fourth day of embryogenesis nucleic acid synthesis drops sharply in these cells. These decreases in metabolic activity preceed the disappearance of the primitive erythrocyte from the chick embryo circulation. It appears that the primitive cell line is specifically shut off with respect to its metabolic activities and possibly destroyed at this time.
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U2 - 10.1002/jcp.1040790113
DO - 10.1002/jcp.1040790113
M3 - Article
C2 - 5009371
AN - SCOPUS:0015291936
SN - 0021-9541
VL - 79
SP - 111
EP - 116
JO - Journal of cellular physiology
JF - Journal of cellular physiology
IS - 1
ER -