Alpha2-adrenoceptor status in obsessive-compulsive disorder

Myung A. Lee; Oliver G. Cameron; George N M Gurguis; Debra Glitz; Charles B. Smith; M. Hariharan; James L. Abelson; George C. Curtis

doi:10.1016/0006-3223(90)90045-4

Alpha₂-adrenoceptor status in obsessive-compulsive disorder

Myung A. Lee, Oliver G. Cameron, George N M Gurguis, Debra Glitz, Charles B. Smith, M. Hariharan, James L. Abelson, George C. Curtis

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Ten patients with obsessive-compulsive disorder (OCD) and 13 normal control subjects received intravenous infusions of 2 × 10^-6 g/kg of clonidine and normal saline on separate days. Responses to the drug relating to plasma growth hormone (GH), 3-methoxy-4-hydroxyphenylglycol (MHPG), heart rate, blood pressure, and several symptoms were determined. Additionally, platelet alpha₂-adrenoceptor binding was measured in most of the subjects. GH, MHPG, blood pressure, and heart rate responses to clonidine did not differ between groups. As expected, patients reported more symptoms than normal subjects, and clonidine was sedating for both groups. Patients did not differ from normal subjects in the symptom response to clonidine. The maximum number of binding sites (B_max) for tritiated clonidine was significantly greater in OCD patients than in normals. This pattern of alpha₂-adrenoceptor status is different than the patterns in major depression and panic anxiety.

Original language	English (US)
Pages (from-to)	1083-1093
Number of pages	11
Journal	Biological Psychiatry
Volume	27
Issue number	10
DOIs	https://doi.org/10.1016/0006-3223(90)90045-4
State	Published - May 15 1990

ASJC Scopus subject areas

Biological Psychiatry

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10.1016/0006-3223(90)90045-4

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@article{fe9998ef26d3404cbf669bd3c693f187,

title = "Alpha2-adrenoceptor status in obsessive-compulsive disorder",

abstract = "Ten patients with obsessive-compulsive disorder (OCD) and 13 normal control subjects received intravenous infusions of 2 × 10-6 g/kg of clonidine and normal saline on separate days. Responses to the drug relating to plasma growth hormone (GH), 3-methoxy-4-hydroxyphenylglycol (MHPG), heart rate, blood pressure, and several symptoms were determined. Additionally, platelet alpha2-adrenoceptor binding was measured in most of the subjects. GH, MHPG, blood pressure, and heart rate responses to clonidine did not differ between groups. As expected, patients reported more symptoms than normal subjects, and clonidine was sedating for both groups. Patients did not differ from normal subjects in the symptom response to clonidine. The maximum number of binding sites (Bmax) for tritiated clonidine was significantly greater in OCD patients than in normals. This pattern of alpha2-adrenoceptor status is different than the patterns in major depression and panic anxiety.",

author = "Lee, {Myung A.} and Cameron, {Oliver G.} and Gurguis, {George N M} and Debra Glitz and Smith, {Charles B.} and M. Hariharan and Abelson, {James L.} and Curtis, {George C.}",

note = "Funding Information: From the Departmentso f Psychiatry (M.A,L., O.G.C., G.N.M.G., D.G., M.H., J.L.A., G.C.C.) and Pharmacology( C.B.S.), Universityo f Michigan Medical Center, Present address: ClevelandV eterans' AdministrationC enter (M.A.L.), the National instituta of Mental Health (G.N.M.G.), and Wayne State Medical Center (D.G.). Address reprintr equests to MyungA e Lee, M.D., ClevelandV A MedicalC enter, PsychiatryS ervice 116A(B), 10000B tec~viile Road, Btecksville, OH 44141. Received June 6, 198'~,r evised September 22, 1989. 1{"}his research was supported in par~b y N'IMHg rant IR01MH42736a nd in part by ClinicalR esearch CenterG rant5 M01RR00042.",

year = "1990",

month = may,

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doi = "10.1016/0006-3223(90)90045-4",

language = "English (US)",

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T1 - Alpha2-adrenoceptor status in obsessive-compulsive disorder

AU - Lee, Myung A.

AU - Cameron, Oliver G.

AU - Gurguis, George N M

AU - Glitz, Debra

AU - Smith, Charles B.

AU - Hariharan, M.

AU - Abelson, James L.

AU - Curtis, George C.

N1 - Funding Information: From the Departmentso f Psychiatry (M.A,L., O.G.C., G.N.M.G., D.G., M.H., J.L.A., G.C.C.) and Pharmacology( C.B.S.), Universityo f Michigan Medical Center, Present address: ClevelandV eterans' AdministrationC enter (M.A.L.), the National instituta of Mental Health (G.N.M.G.), and Wayne State Medical Center (D.G.). Address reprintr equests to MyungA e Lee, M.D., ClevelandV A MedicalC enter, PsychiatryS ervice 116A(B), 10000B tec~viile Road, Btecksville, OH 44141. Received June 6, 198'~,r evised September 22, 1989. 1"his research was supported in par~b y N'IMHg rant IR01MH42736a nd in part by ClinicalR esearch CenterG rant5 M01RR00042.

PY - 1990/5/15

Y1 - 1990/5/15

N2 - Ten patients with obsessive-compulsive disorder (OCD) and 13 normal control subjects received intravenous infusions of 2 × 10-6 g/kg of clonidine and normal saline on separate days. Responses to the drug relating to plasma growth hormone (GH), 3-methoxy-4-hydroxyphenylglycol (MHPG), heart rate, blood pressure, and several symptoms were determined. Additionally, platelet alpha2-adrenoceptor binding was measured in most of the subjects. GH, MHPG, blood pressure, and heart rate responses to clonidine did not differ between groups. As expected, patients reported more symptoms than normal subjects, and clonidine was sedating for both groups. Patients did not differ from normal subjects in the symptom response to clonidine. The maximum number of binding sites (Bmax) for tritiated clonidine was significantly greater in OCD patients than in normals. This pattern of alpha2-adrenoceptor status is different than the patterns in major depression and panic anxiety.

AB - Ten patients with obsessive-compulsive disorder (OCD) and 13 normal control subjects received intravenous infusions of 2 × 10-6 g/kg of clonidine and normal saline on separate days. Responses to the drug relating to plasma growth hormone (GH), 3-methoxy-4-hydroxyphenylglycol (MHPG), heart rate, blood pressure, and several symptoms were determined. Additionally, platelet alpha2-adrenoceptor binding was measured in most of the subjects. GH, MHPG, blood pressure, and heart rate responses to clonidine did not differ between groups. As expected, patients reported more symptoms than normal subjects, and clonidine was sedating for both groups. Patients did not differ from normal subjects in the symptom response to clonidine. The maximum number of binding sites (Bmax) for tritiated clonidine was significantly greater in OCD patients than in normals. This pattern of alpha2-adrenoceptor status is different than the patterns in major depression and panic anxiety.

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JO - Biological Psychiatry

JF - Biological Psychiatry

IS - 10

ER -

Alpha₂-adrenoceptor status in obsessive-compulsive disorder

Abstract

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