Alpha2-adrenoceptor status in obsessive-compulsive disorder

Myung A. Lee, Oliver G. Cameron, George N M Gurguis, Debra Glitz, Charles B. Smith, M. Hariharan, James L. Abelson, George C. Curtis

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


Ten patients with obsessive-compulsive disorder (OCD) and 13 normal control subjects received intravenous infusions of 2 × 10-6 g/kg of clonidine and normal saline on separate days. Responses to the drug relating to plasma growth hormone (GH), 3-methoxy-4-hydroxyphenylglycol (MHPG), heart rate, blood pressure, and several symptoms were determined. Additionally, platelet alpha2-adrenoceptor binding was measured in most of the subjects. GH, MHPG, blood pressure, and heart rate responses to clonidine did not differ between groups. As expected, patients reported more symptoms than normal subjects, and clonidine was sedating for both groups. Patients did not differ from normal subjects in the symptom response to clonidine. The maximum number of binding sites (Bmax) for tritiated clonidine was significantly greater in OCD patients than in normals. This pattern of alpha2-adrenoceptor status is different than the patterns in major depression and panic anxiety.

Original languageEnglish (US)
Pages (from-to)1083-1093
Number of pages11
JournalBiological Psychiatry
Issue number10
StatePublished - May 15 1990

ASJC Scopus subject areas

  • Biological Psychiatry


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