Alpha-Fetoprotein-Producing Esophageal Adenocarcinoma With Enteroblastic, Yolk Sac Tumor-Like, and Hepatoid Carcinoma Differentiation: A Rare Case and Literature Review

Karen Tina Shore, Kara Chan Phelps, Jyoti Balani, James Michael Mitchell

Research output: Contribution to journalArticlepeer-review

Abstract

We report a case of a 65-year-old man with alpha-fetoprotein (AFP)-producing esophageal adenocarcinoma that microscopically consisted of a polymorphous blend of enteroblastic, yolk sac-like, and hepatoid carcinoma components of variable proportions. No histological evidence of Barrett's esophagus was identified. Two weeks post-endoscopic mucosal mass resection, the serum AFP level was 1434.6 ng/mL. The patient underwent radiation and chemotherapy but developed metastatic lung lesions. At 18 months post-resection, the patient is alive. AFP-producing esophageal adenocarcinoma is a rare entity. We reviewed reported cases for clinicopathological features, treatment strategies, and prognosis.

Original languageEnglish (US)
Pages (from-to)884-889
Number of pages6
JournalInternational Journal of Surgical Pathology
Volume31
Issue number5
DOIs
StatePublished - Aug 2023

Keywords

  • alpha-fetoprotein
  • enteroblastic
  • esophageal adenocarcinoma
  • hepatoid
  • yolk sac-like

ASJC Scopus subject areas

  • Surgery
  • Anatomy
  • Pathology and Forensic Medicine

Fingerprint

Dive into the research topics of 'Alpha-Fetoprotein-Producing Esophageal Adenocarcinoma With Enteroblastic, Yolk Sac Tumor-Like, and Hepatoid Carcinoma Differentiation: A Rare Case and Literature Review'. Together they form a unique fingerprint.

Cite this