Abstract
We report a case of a 65-year-old man with alpha-fetoprotein (AFP)-producing esophageal adenocarcinoma that microscopically consisted of a polymorphous blend of enteroblastic, yolk sac-like, and hepatoid carcinoma components of variable proportions. No histological evidence of Barrett's esophagus was identified. Two weeks post-endoscopic mucosal mass resection, the serum AFP level was 1434.6 ng/mL. The patient underwent radiation and chemotherapy but developed metastatic lung lesions. At 18 months post-resection, the patient is alive. AFP-producing esophageal adenocarcinoma is a rare entity. We reviewed reported cases for clinicopathological features, treatment strategies, and prognosis.
Original language | English (US) |
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Pages (from-to) | 884-889 |
Number of pages | 6 |
Journal | International Journal of Surgical Pathology |
Volume | 31 |
Issue number | 5 |
DOIs | |
State | Published - Aug 2023 |
Keywords
- alpha-fetoprotein
- enteroblastic
- esophageal adenocarcinoma
- hepatoid
- yolk sac-like
ASJC Scopus subject areas
- Surgery
- Anatomy
- Pathology and Forensic Medicine