Allopurinol-induced palisaded neutrophilic and granulomatous dermatitis

Katherine Gordon, Maria Miteva, Daniele Torchia, Paolo Romanelli

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


We describe a 64-year-old man with past chronic myeloid leukemia. Palisading neutrophilic granulomatous dermatitis of the hands was diagnosed and related to recent allopurinol intake. Allopurinol is known to rarely cause granulomatous reactions, but this appears to be the first case of palisading neutrophilic granulomatous dermatitis induction. Possible mechanisms include immune complex deposition, an immune response directed against the metabolites of allopurinol, or allopurinol hypersensitivity exclusively localized to the skin.

Original languageEnglish (US)
Pages (from-to)338-340
Number of pages3
JournalCutaneous and Ocular Toxicology
Issue number4
StatePublished - Dec 2012


  • Allopurinol
  • Drug reaction
  • Palisaded neutrophilic and granulomatous dermatitis

ASJC Scopus subject areas

  • Toxicology


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