Allergic rhinitis with negative skin tests

Michael L. Alvares, David A. Khan

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


Recently, several studies have revealed a subset of patients who have positive nasal provocation to allergens despite having a negative skin prick test. It has been hypothesized that these patients have localized allergic rhinitis. However, the prevalence varies greatly, ranging from 0% to 100% of skin test-negative individuals. This wide range in prevalence is likely related to differences in methodology, including differences in allergen manufacturers, concentrations, and numbers of allergens tested and, perhaps most importantly, criteria for a positive nasal challenge. Despite the evidence to date, many challenges exist with regard to the concept of localized nasal allergy. Further studies will be required to further define the immunopathology, prevalence, practical diagnostic tests, and management.

Original languageEnglish (US)
Pages (from-to)107-114
Number of pages8
JournalCurrent Allergy and Asthma Reports
Issue number2
StatePublished - Apr 1 2011


  • Allergic
  • Localized
  • Nasal provocation
  • Negative skin test
  • Rhinitis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pulmonary and Respiratory Medicine


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