TY - JOUR
T1 - Aldosterone Synthase Promoter Polymorphism and Cardiovascular Phenotypes in a Large, Multiethnic Population-Based Study
AU - Byrd, James Brian
AU - Auchus, Richard J.
AU - White, Perrin C.
N1 - Publisher Copyright:
© Lippincott Williams and Wilkins.
PY - 2015/10/1
Y1 - 2015/10/1
N2 - Background A single-nucleotide polymorphism in the aldosterone synthase gene (CYP11B2) promoter [-344C/T, rs1799998] has been reported to associate with cardiovascular phenotypes. Methods The Dallas Heart Study is a large, multiethnic cohort with a high prevalence of hypertension. We genotyped 3452 Dallas Heart Study participants for-344C/T. Generalized linear models were used to assess whether variation at-344C/T associated with plasma aldosterone concentration (PAC), systolic and diastolic blood pressure (SBP and DBP), plasma glucose (in persons with no diabetes), HOMA IR (Homeostasis Model Assessment as an Index of Insulin Resistance), and left ventricular (LV) mass indexed to height. Systolic blood pressure and DBP were significantly higher in blacks compared with whites (P < 0.001 for SBP and for DBP) and Hispanics (P < 0.001 for SBP and for DBP). Log-transformed body mass index was also significantly higher in blacks compared with whites (P < 0.001), but not Hispanics (P = 0.10). Log-transformed PAC was higher in whites compared with blacks (P < 0.001), but did not differ significantly in whites compared with Hispanics (P = 0.73). In univariate and multivariable analysis,-344C/T was not significantly associated with PAC within any ethnicity. In univariate and multivariable analysis,-344C/T was not associated with SBP or DBP within any ethnicity. After adjustment for multiple testing, univariate and multivariable analyses revealed no association between-344C/T and plasma glucose in patients with no diabetes, HOMA IR, or LV mass indexed to height. Conclusions We were unable to reproduce previously reported associations between-344C/T and PAC, blood pressure, plasma glucose, or LV mass. Methodological differences might explain the differences between our findings and those previously reported.
AB - Background A single-nucleotide polymorphism in the aldosterone synthase gene (CYP11B2) promoter [-344C/T, rs1799998] has been reported to associate with cardiovascular phenotypes. Methods The Dallas Heart Study is a large, multiethnic cohort with a high prevalence of hypertension. We genotyped 3452 Dallas Heart Study participants for-344C/T. Generalized linear models were used to assess whether variation at-344C/T associated with plasma aldosterone concentration (PAC), systolic and diastolic blood pressure (SBP and DBP), plasma glucose (in persons with no diabetes), HOMA IR (Homeostasis Model Assessment as an Index of Insulin Resistance), and left ventricular (LV) mass indexed to height. Systolic blood pressure and DBP were significantly higher in blacks compared with whites (P < 0.001 for SBP and for DBP) and Hispanics (P < 0.001 for SBP and for DBP). Log-transformed body mass index was also significantly higher in blacks compared with whites (P < 0.001), but not Hispanics (P = 0.10). Log-transformed PAC was higher in whites compared with blacks (P < 0.001), but did not differ significantly in whites compared with Hispanics (P = 0.73). In univariate and multivariable analysis,-344C/T was not significantly associated with PAC within any ethnicity. In univariate and multivariable analysis,-344C/T was not associated with SBP or DBP within any ethnicity. After adjustment for multiple testing, univariate and multivariable analyses revealed no association between-344C/T and plasma glucose in patients with no diabetes, HOMA IR, or LV mass indexed to height. Conclusions We were unable to reproduce previously reported associations between-344C/T and PAC, blood pressure, plasma glucose, or LV mass. Methodological differences might explain the differences between our findings and those previously reported.
KW - aldosterone
KW - genetics
KW - glucose
KW - hypertension
KW - left ventricular mass
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U2 - 10.1097/JIM.0000000000000220
DO - 10.1097/JIM.0000000000000220
M3 - Article
C2 - 26200036
AN - SCOPUS:84943165703
SN - 1708-8267
VL - 63
SP - 862
EP - 866
JO - Journal of Investigative Medicine
JF - Journal of Investigative Medicine
IS - 7
ER -